BDB565480
CD44 Rat anti-Mouse, APC-R700, Clone: IM7, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB565480-Each-of-1 | In Stock | ₹ 18,309.84 |
BDB565480 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 18,309.84
GST (18%): ₹ 3,295.771
Total Price: ₹ 21,605.611
Antigen
CD44
Classification
Monoclonal
Concentration
0.2mg/mL
Description
Pgp-1; Ly-24; H-CAM; HERMES; ECMR-III; Hyaluronate Receptor
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG2b κ
Applications
Flow Cytometry
Clone
IM7
Conjugate
APC-R700
Formulation
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen
Dexamethasone-induced, SJL mouse spontaneous myeloid leukemia M1 cells myeloid leukemia M1
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Description
- The IM7 antibody specifically recognizes an epitope on both alloantigens and all isoforms of the CD44 glycoprotein (Pgp-1, Ly-24)
- The standard form of CD44, lacking variable exons and referred to as CD44H or CD44s, is widely expressed on hematopoietic and non-hematopoietic cells
- CD44 isoforms encoded by variable exons are expressed on epithelial cells, but only at low levels on most leukocytes
- Mice with the Ly-24.1 alloantigen (e.g., BALB/c, CBA/J, DBA/1, DBA/2) have relatively large subsets of CD44H+ T lymphocytes, while Ly-24.2 strains (e.g., A, AKR, CBA/N, C3H/He, C57BL, C57BR, C57L, C58, NZB, SJL, SWR, 129) have fewer CD44H+ T cells
- CD44 is a cell adhesion receptor, and its principal ligand, hyaluronate, is a common component of extracellular matrices
- Differential glycosylation of CD44 influences its binding to hyaluronate
- Additional ligands include the cell-surface form of CD74 and the cytokine osteopontin (Eta-1)
- Bone marrow- and thymus-derived progenitor cells capable of repopulating the thymus express CD44
- In the periphery, the level of CD44 expression increases upon activation of B lymphocytes, CD4+ T cells, and CD8+ T cells; memory cells can be recognized by their CD44[hi] phenotype
- The IM7 mAb inhibits established collagen-induced arthritis in DBA/1 mice
- Moreover, it prevents CNS inflammation and clinical symptoms of experimental autoimmune encephalomyelitis
- In contrast, the same antibody exacerbates experimental autoimmune thyroiditis in CBA/J mice
- The IM7 mAb recognizes a different epitope from that recognized by mAb KM114, and the antibody pair can be used in ELISA to detect soluble CD44
- It has been observed that IM7 antibody crossreacts with human, dog, cat, horse, cow, and pig leukocytes
- Anti-human CD44, clone G44-26, and IM7 antibody compete for binding to human peripheral blood lymphocytes
- This antibody was conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700
- APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness
- This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45-nm filter).
Compare Similar Items
Show Difference
Antigen: CD44
Classification: Monoclonal
Concentration: 0.2mg/mL
Description: Pgp-1; Ly-24; H-CAM; HERMES; ECMR-III; Hyaluronate Receptor
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG2b κ
Applications: Flow Cytometry
Clone: IM7
Conjugate: APC-R700
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen: Dexamethasone-induced, SJL mouse spontaneous myeloid leukemia M1 cells myeloid leukemia M1
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD44
Classification:
Monoclonal
Concentration:
0.2mg/mL
Description:
Pgp-1; Ly-24; H-CAM; HERMES; ECMR-III; Hyaluronate Receptor
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG2b κ
Applications:
Flow Cytometry
Clone:
IM7
Conjugate:
APC-R700
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen:
Dexamethasone-induced, SJL mouse spontaneous myeloid leukemia M1 cells myeloid leukemia M1
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD3
Classification: Monoclonal
Concentration: __
Description: Vol. Per test: 5μL
Host Species: Mouse
Purification Method: __
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: UCHT1
Conjugate: Brilliant Violet 786
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Human infant thymocytes and peripheral blood lymphocytes from a Sézary Syndrome donor
Quantity: 50 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with BD Horizon™ BV786 under optimum conditions, and unconjugated antibody and free BD Horizon™ BV786 were removed.
Antigen:
CD3
Classification:
Monoclonal
Concentration:
__
Description:
Vol. Per test: 5μL
Host Species:
Mouse
Purification Method:
__
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
UCHT1
Conjugate:
Brilliant Violet 786
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Human infant thymocytes and peripheral blood lymphocytes from a Sézary Syndrome donor
Quantity:
50 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with BD Horizon™ BV786 under optimum conditions, and unconjugated antibody and free BD Horizon™ BV786 were removed.
Antigen: Sox 9
Classification: Monoclonal
Concentration: 0.2mg/mL
Description: __
Host Species: Mouse
Purification Method: __
Regulatory Status: RUO
Target Species: Human, Rat
Isotype: IgG1 κ
Applications: Flow Cytometry, Flow Cytometry (Intracellular Staining)
Clone: T32-668
Conjugate: Alexa Fluor 647
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen: Human Sox9 Recombinant Protein
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to Alexa Fluor™ 647 under optimum conditions and unreacted Alexa Fluor™ 647 was removed.
Antigen:
Sox 9
Classification:
Monoclonal
Concentration:
0.2mg/mL
Description:
__
Host Species:
Mouse
Purification Method:
__
Regulatory Status:
RUO
Target Species:
Human, Rat
Isotype:
IgG1 κ
Applications:
Flow Cytometry, Flow Cytometry (Intracellular Staining)
Clone:
T32-668
Conjugate:
Alexa Fluor 647
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen:
Human Sox9 Recombinant Protein
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to Alexa Fluor™ 647 under optimum conditions and unreacted Alexa Fluor™ 647 was removed.
Antigen: MLC2a
Classification: Monoclonal
Concentration: 0.5mg/mL
Description: __
Host Species: Mouse
Purification Method: __
Regulatory Status: RUO
Target Species: Human, Mouse
Isotype: IgG1 κ
Applications: Flow Cytometry, Flow Cytometry (Intracellular Staining)
Clone: S58-205
Conjugate: Unconjugated
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Human MLC2a Recombinant Protein
Quantity: 0.1 mg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Antigen:
MLC2a
Classification:
Monoclonal
Concentration:
0.5mg/mL
Description:
__
Host Species:
Mouse
Purification Method:
__
Regulatory Status:
RUO
Target Species:
Human, Mouse
Isotype:
IgG1 κ
Applications:
Flow Cytometry, Flow Cytometry (Intracellular Staining)
Clone:
S58-205
Conjugate:
Unconjugated
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Human MLC2a Recombinant Protein
Quantity:
0.1 mg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.