BDB565565
TIM-3 (CD366) Mouse anti-Human, Brilliant Violet 650, Clone: 7D3, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB565565-Each-of-1 | In Stock | ₹ 20,277.72 |
BDB565565 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 20,277.72
GST (18%): ₹ 3,649.99
Total Price: ₹ 23,927.71
Antigen
TIM-3 (CD366)
Clone
7D3
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Classification
Monoclonal
Conjugate
Brilliant Violet 650
Gene Alias
CD366, HAVCR2, TIM3, T cell immunoglobulin mucin-3, TIMD-3, KIM-3
Immunogen
Human TIM-3
Quantity
25 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Description
- The 7D3 monoclonal antibody specifically binds to T cell immunoglobulin mucin 3 (TIM-3) which is also known as, CD366, or T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3/TIMD3)
- CD366 is encoded by the HAVCR2 /gene (Hepatitis A virus cellular receptor 2)
- CD366 is a type I transmembrane glycoprotein and belongs to the human TIM family (along with TIM-1 and TIM-4) within the immunoglobulin superfamily
- CD366 is expressed on Th1, Tc1, Th17, Treg, NK T, and NK cells
- CD366 is also expressed on dendritic cells, mast cells, monocytes, and macrophages
- It is not expressed by Th2 and B cells
- CD366 helps maintain peripheral immune tolerance and homeostasis
- CD366 regulates macrophage activation and is a negative regulator of Th1 cell function
- Crosslinking of cell surface CD366 by binding to Galectin-9 and/or phosphatidylserine appears to play an important role in either positively or negatively regulating leucocyte functions, such as cytokine production or the phagocytosis of apoptotic cells
- CD366 may also be useful as an AML stem cell surface marker because it appears to be more highly expressed by AML leukemia stem cells than by normal bone marrow hematopoietic stem cells
- The antibody was conjugated to BD Horizon BV650 which is part of the BD Horizon Brilliant™ Violet family of dyes
- This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 650nm
- BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20nm filter)
- Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors
- However, the spillover can be corrected through compensation as with any other dye combination
- BV650 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 650 nm
- Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors
- BV650 will have moderate spillover into the BD Horizon™ BV711 detector.
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Antigen: TIM-3 (CD366)
Clone: 7D3
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Classification: Monoclonal
Conjugate: Brilliant Violet 650
Gene Alias: CD366, HAVCR2, TIM3, T cell immunoglobulin mucin-3, TIMD-3, KIM-3
Immunogen: Human TIM-3
Quantity: 25 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
TIM-3 (CD366)
Clone:
7D3
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Classification:
Monoclonal
Conjugate:
Brilliant Violet 650
Gene Alias:
CD366, HAVCR2, TIM3, T cell immunoglobulin mucin-3, TIMD-3, KIM-3
Immunogen:
Human TIM-3
Quantity:
25 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: TIM-3 (CD366)
Clone: 7D3
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: __
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Classification: Monoclonal
Conjugate: Brilliant Blue 515 (BB515)
Gene Alias: CD366; HAVCR2; TIM3; T cell immunoglobulin mucin-3; TIMD-3; KIM-3
Immunogen: Human TIM-3
Quantity: 100 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with BD Horizon™ BB515 under optimum conditions and unconjugated antibody was removed.
Antigen:
TIM-3 (CD366)
Clone:
7D3
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
__
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Classification:
Monoclonal
Conjugate:
Brilliant Blue 515 (BB515)
Gene Alias:
CD366; HAVCR2; TIM3; T cell immunoglobulin mucin-3; TIMD-3; KIM-3
Immunogen:
Human TIM-3
Quantity:
100 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with BD Horizon™ BB515 under optimum conditions and unconjugated antibody was removed.
Antigen: TIM-3 (CD366)
Clone: 7D3
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: __
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Classification: Monoclonal
Conjugate: Brilliant Blue 515 (BB515)
Gene Alias: CD366; HAVCR2; TIM3; T cell immunoglobulin mucin-3; TIMD-3; KIM-3
Immunogen: Human TIM-3
Quantity: 25 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with BD Horizon™ BB515 under optimum conditions and unconjugated antibody was removed.
Antigen:
TIM-3 (CD366)
Clone:
7D3
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
__
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Classification:
Monoclonal
Conjugate:
Brilliant Blue 515 (BB515)
Gene Alias:
CD366; HAVCR2; TIM3; T cell immunoglobulin mucin-3; TIMD-3; KIM-3
Immunogen:
Human TIM-3
Quantity:
25 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with BD Horizon™ BB515 under optimum conditions and unconjugated antibody was removed.
Antigen: TIM-3 (CD366)
Clone: 7D3
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: __
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Classification: Monoclonal
Conjugate: PE
Gene Alias: CD366; HAVCR2; TIM3; T cell immunoglobulin mucin-3; TIMD-3; KIM-3
Immunogen: Human TIM-3
Quantity: 25 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions and unconjugated antibody and free PE were removed.
Antigen:
TIM-3 (CD366)
Clone:
7D3
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
__
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Classification:
Monoclonal
Conjugate:
PE
Gene Alias:
CD366; HAVCR2; TIM3; T cell immunoglobulin mucin-3; TIMD-3; KIM-3
Immunogen:
Human TIM-3
Quantity:
25 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions and unconjugated antibody and free PE were removed.