Granzyme B Mouse, anti-Human, R718, Clone: GB11, BD Horizon™

Description

• Description The GB11 antibody specifically reacts with human granzyme B, a serine protease of approximately 32 kDa
• Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin
• In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes
• Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis
• Granzyme B may also be involved in the hydrolysis of extracellular matrix components
• Detectable levels of granzyme B have been detected in sera from healthy volunteers
• The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from an NK cell line.