IL-4 Mouse, anti-Human, R718, Clone: MP4-25D2, BD Horizon™

Description

• The MP4-25D2 monoclonal antibody specifically binds to Interleukin-4 (IL-4)
• IL-4 is also known as Lymphocyte stimulatory factor 1, B cell stimulatory factor 1 (BSF-1), or B cell growth factor 1 (BCGF-1)
• IL-4 is produced by activated T cells, basophils, and mast cells
• IL-4 is a multifunctional cytokine and growth factor that affects a variety of different target cell types
• IL-4 can costimulate T cell proliferation and survival, as well as help drive Th2-like cell differentiation and effector functions
• It costimulates B cell proliferation and survival, and can help B cells differentiate into IgG4- or IgE-producing cells
• IL-4 can also diminish the proinflammatory functions of monocytes and macrophages
• IL-4 exerts its biological effects by binding with high affinity to cell surface CD124 (IL-4Rα chain)
• CD124 forms signaling IL-4 receptor complexes with either CD132/common γ chain or CD213a1/IL-13Rα1 to form either Type I or Type II IL-4 Receptor complexes, respectively
• The immunogen used to generate the MP4-25D2 hybridoma was purified recombinant human IL-4
• This is a neutralizing antibody
• The MP4-25D2 antibody has been reported to crossreact with IL-4 from rhesus monkeys
• The use of the MP4-25D2 antibody for epitope mapping of human IL-4 has been described.