PKCε Mouse, Unlabeled, Clone: 21, BD

Description

• The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion
• At least eleven isozymes have been described
• These proteins are products of multiple genes and alternative splicing
• PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V)
• The N-terminal half containing C1, C2, V1, and V2 constitutes the regulatory domain and interacts with PKC activators Ca2), phospholipid, diacylglycerol, or phorbol ester
• However, the novel PKC (nPKC) subfamily members (δ, η, η, and θ isoforms) and the atypical PKC (aPKC) subfamily members (ζ , ι , and λ isoforms) are Ca(2+) independent and lack the C2 domain
• The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters and growth factors
• Expression of the 90kDa PKCα is induced by interferon-α
• Generally, PKCα is expressed at very low levels in normal murine tissues, except brain
• Overexpression of PKCα leads to increased growth rates and higher cell densities in monolayer cultures
• A high level of expression is seen in several hematopoietic cell lines and tumors
• This suggests a possible role for PKCα in tumorigenesis
• Host Species: Mouse Clone: 21 Isotype: IgG2a Species Reactivity: Rat Immunogen: Human PKCε aa
• 1-175 Formula Weight [Chemical]: 90kDa Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting