NMDAR2B Mouse, Unlabeled, Clone: 13, BD

Description

• The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation
• Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic
• The ionotropic receptors are subdivided into two distint types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate
• Three types of NMDAR2 have been identified: NR2A, NR2B, and NR2C
• NR2A and NR2B contain a C-terminal extension (>600 amino acids) that has small scattered regions of conserved sequence
• The three NR2 mRNAs show overlapping, differential expression patterns in the rat brain
• NR2B has been reported to be expressed in the forebrain, thalamic nuclei, amygdaloid nuclei, caudateputamen, and in restricted regions of the olfactory bulb
• Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting