Caveolin 3 Mouse, Unlabeled, Clone: 26, BD

Description

• Identified as a tyrosine phosphorylated protein in Rous sarcoma virus-transformed chick embryo fibroblasts (CEF), caveolin is now known to be ubiquitously expressed
• Caveolin (also known as VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane
• This transmembrane protein plays a structural role in these specializations
• Caveolin is also present at the trans-Golgi network (TGN), and similar quantities are found in apically and basolaterally destined transport vesicles
• Caveolin is part of a complex containing glycosylphosphatidylinositol (GPI)-linked molecules and cytoplasmic signaling proteins
• Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, Annexin II, and hetero-trimeric G proteins
• Caveolin 3 has been identified as a distinct isoform which is expressed only in smooth, skeletal, and cardiac muscle
• This antibody is routinely tested by western blot analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.