CD100 Mouse, Unlabeled, Clone: 30, BD

Description

• CD100 was originally described as a 150 kDa surface T-cell antigen induced after T-cell activation
• Human CD100 exhibits widespread gene expression but is most prominent in peripheral lymphocytes, thymus, skeletal muscle, and brain
• The full CD100 protein is 862 amino acids with homolgy to the semaphorin family of proteins at its extracellular domain followed by a short Ig-like domain
• The short cytoplasmic domain contains a putative tyrosine phosphorylation site which may be the site for association with intracellular kinases
• Cells that overexpress CD100 induce a rapid aggregation of B cells and increase the CD90L-B cell aggregation
• Because semaphorins are axon-guiding molecules for the nervous system, it has been proposed that CD100 may have a guidance role in the immune system.