CD54 (ICAM-1) Mouse anti-Human, Unlabeled, Clone: 28, BD

Description

• The migration of T cells through lymph nodes and their interactions with antigen presenting cells (APCs) involve adhesion molecules on the surfaces of the T cell and the cell with which it interacts
• These molecules include the selectins, the integrins, members of the immunoglobulin superfamily, and some mucin-like proteins
• The integrins mediate adhesion between cells and between cells and the extracellular matrix
• LFA-1 (lymphocyte function-associated antigen 1), a member of the β2 integrin family, is expressed on T cells, neutrophils, and macrophages and is thought to be the most important adhesion molecule for lymphocyte activation
• It interacts with members of the immunoglobulin superfamily, the intercellular adhesion molecules: ICAM-1, -2, and -3
• ICAM-1 and ICAM-2 are expressed on endodthelium and APCs, while ICAM-3 is expressed only on leukocytes
• ICAM-1 is most homologous to neural cell adhesion molecule and myelin-associated glycoprotein
• It is a 55kDa glycoprotein that is heavily glycosylated to form 90kDa to 115kDa proteins
• Its interactions with LFA-1 are necessary for CTL and NK mediated killing, T and B cell responses, and immune cell extravasation
• Host Species: Mouse Clone: 28 Isotype: IgG1 Species Reactivity [for Features Main]: Human Immunogen: Human CD54/ICAM-1 aa
• 46-160 Immunofluorescence, Western Blotting