BDB641400

CD8 Mouse anti-Human, APC-H7, Clone: SK1, BD

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB641400-Each-of-1 In Stock ₹ 57,924.12

BDB641400 - Each of 1

₹ 57,924.12

In Stock

Quantity

1

Base Price: ₹ 57,924.12

GST (18%): ₹ 10,426.342

Total Price: ₹ 68,350.462

Antigen

CD8

Classification

Monoclonal

Concentration

50μg/mL

Formulation

Phosphate buffered saline with gelatin and 0.1% sodium azide.

Immunogen

Human Peripheral Blood T Cells

Quantity

100 Tests

Research Discipline

Immunology

Target Species

Human

Isotype

IgG1 κ

Applications

Flow Cytometry

Clone

SK1

Conjugate

APC-H7

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store vials at 2-8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.

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Description

  • CD8 clone SK1 is derived from hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with human peripheral blood T lymphocytes
  • The CD8 antibody recognizes the 32-kilodalton (kDa) α-subunit of a disulfide-linked bimolecular complex
  • The majority of peripheral blood CD8 + T lymphocytes express an α/β heterodimer (Mr 32, 30 kDa), while CD8 The CD8 antibody recognizes the 32-kilodalton (kDa) α-subunit of a disulfide-linked bimolecular complex
  • The majority of peripheral blood CD8 + T lymphocytes express an α/β heterodimer (Mr 32, 30 kDa), while CD8 + CD16 + natural killer (NK) lymphocytes and CD8 + T-cell receptor (TCR)-γ/δ + T lymphocytes express an α/α homodimer (Mr 30 kDa)
  • CD8 + TCR-α/β + T lymphocytes can express either an α/α homodimer or α/β heterodimer
  • The CD8 antigenic determinant binds to class I major histocompatibility (MHC) molecules, resulting in increased adhesion between the CD8 + T lymphocytes and target cells
  • Binding of the CD8 antigen to class I MHC molecules enhances the activation of resting T lymphocytes
  • The CD8 antigen is coupled to a protein tyrosine kinase, p56 lck
  • The CD8:p56 lck complex can play a role in T-lymphocyte activation through mediation of the interactions between the CD8 antigen and the CD3/TCR complex.

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Antigen:
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Classification:
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Concentration:
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Formulation:
Phosphate buffered saline with gelatin and 0.1% sodium azide.

Immunogen:
Human Peripheral Blood T Cells

Quantity:
100 Tests

Research Discipline:
Immunology

Target Species:
Human

Isotype:
IgG1 κ

Applications:
Flow Cytometry

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Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Primary or Secondary:
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Store vials at 2-8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.

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