IL-10Rbeta (CD210b) Mouse anti-Human, Brilliant Violet 421, Clone: 90220, BD Optibuild™

Description

• The 90220 monoclonal antibody specifically binds to the beta subunit (IL-10R beta/IL-10RB/IL-10R β ) of the heteromeric IL-10 Receptor complex
• This type I transmembrane glycoprotein is also known as, subunit 2 (IL-10R2) or CD210b
• The IL-10 Receptor complex is formed by the binding of dimeric IL-10 to two cell surface alpha subunits of the IL-10 Receptor (CD210a/IL-10RA/IL-10R α )
• This complex can then recruit two CD210b subunits resulting in the transduction of intracellular JAK/STAT pathway signals
• CD210b is also a component of cytokine receptor complexes specific for IL-22, IL-26, IL-28 and IL-29
• CD210b is expressed by a variety of cell types including T cells, B cells, NK cells, monocytes and macrophages
• The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes
• With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter)
• BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.