CD49b Hamster anti-Mouse, Brilliant Violet 510, Clone: HMα2, BD Optibuild™

Description

• The HM α 2 antibody reacts with integrin α 2 chain (CD49b), the 150-kDa transmembrane glycoprotein that non-covalently associates with the integrin β 1 subunit (CD29) to form the integrin α 2β 1 complex known as VLA-2
• VLA-2, a receptor for collagen and laminin, is expressed on some splenic CD4+ T lymphocytes and NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, splenic NK cells, epithelial cells, and platelets; but it is not on thymocytes or Peyer’s-patch or lymphnode lymphocytes
• The expression of VLA-2 is upregulated on lymphocytes in response to mitogens
• The HM α 2 antibody has been reported to partially block the interaction of T-cell blasts, but not NK cells, with collagen
• Purified HM α The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes
• With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50-nm) filter set
• BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser.