CD160 Rat anti-Mouse, Brilliant Violet 786, Clone: CNX46-3, BD Optibuild™

Description

• The CNX46-3 monoclonal antibody specifically binds to mouse CD160, also known as Natural Killer Cell Receptor BY55
• CD160 is a glycosyolphosphatidylinositol-anchored membrane glycoprotein that contains a single Ig domain
• This member of the Ig Superfamily was the first identified as a MHC Class I antigen-specific Ig-like Receptor that was expressed by mouse NK cells
• As a receptor, CD160 can bind to classical and non-classical MHC class I molecules with low affinity
• As a ligand, CD160 can bind to HVEM (Herpes Virus Entry Mediator, a TNF Receptor Family Member)
• CD160 is expressed on a subset of NK cells, NKT cells, activated CD8+ T cells and TCR γδ T cells
• The functions of CD160 have been reported to regulate NK cell activation both positively and negatively, depending on the stimulus
• The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes
• This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 786-nm
• BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60-nm filter).