BDB742327
MIC A/B Mouse anti-Human, Brilliant Violet 786, Clone: 6D4, BD Optibuild™
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB742327-Each-of-1 | In Stock | ₹ 49,528.50 |
BDB742327 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,528.50
GST (18%): ₹ 8,915.13
Total Price: ₹ 58,443.63
Antigen
MIC A/B
Clone
6D4
Conjugate
Brilliant Violet 786
Gene Alias
MHC class I polypeptide-related sequence A/B, PERB11.1/ PERB11.2
Immunogen
MICA transfected cells
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification
Monoclonal
Concentration
0.2mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG2a κ
Description
- The 6D4 monoclonal antibody specifically binds to the human MHC class I polypeptide-related sequence A (MICA, aka /PERB11.1) and B (MICB
- aka /PERB11.2) proteins
- These ñ70 kDa transmembrane glycoproteins are homologs of the major histocompatibility complex class I molecules although they lackassociation with β2 microglobulin
- The MHC class I-related MICA and MICB chains are expressed by some gut epithelial cells in vivo
- MICA and MICB expression by other epithelial cells and cell types, including fibroblasts and endothelial cells, is induced by stress, eg, stress caused by bacterial and viral infections, autoimmunity or cellular transformation
- Epithelial cell expression of MICA and MICB has also been detected in transplanted kidneys and pancreas that show histological signs of rejection and or cellular injury
- This suggests their potential role in transplant immunopathology
- MICA and MICB are ligands for NKG2D (CD314), an activating receptor expressed by natural killer (NK) cells,γδ T cells,CD8+ andsome CD4+ αβ T cells
- The 6D4 antibody reportedly blocks NKG2D-positive NK cell- and T cell-mediated cytotoxicity against MICA/B-positive target cells
- The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes
- This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 786nm
- BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60nm filter)
- BV786 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 786 nm
- BV786 offers a bright choice for the 6th detector off the violet laser.
Compare Similar Items
Show Difference
Antigen: MIC A/B
Clone: 6D4
Conjugate: Brilliant Violet 786
Gene Alias: MHC class I polypeptide-related sequence A/B, PERB11.1/ PERB11.2
Immunogen: MICA transfected cells
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG2a κ
Antigen:
MIC A/B
Clone:
6D4
Conjugate:
Brilliant Violet 786
Gene Alias:
MHC class I polypeptide-related sequence A/B, PERB11.1/ PERB11.2
Immunogen:
MICA transfected cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ
Antigen: IgM[b]
Clone: AF6-78
Conjugate: Brilliant Violet 605
Gene Alias: Igh-6b
Immunogen: C57BL/10 mouse splenocytes
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG1 κ
Antigen:
IgM[b]
Clone:
AF6-78
Conjugate:
Brilliant Violet 605
Gene Alias:
Igh-6b
Immunogen:
C57BL/10 mouse splenocytes
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG1 κ
Antigen: CD49a
Clone: SR84
Conjugate: Brilliant Violet 421
Gene Alias: Integrin α1, Integrin alpha-1, ITGA1, ITA1, VLA-1, VLA1
Immunogen: P-Selectin IgG1 Fusion
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Antigen:
CD49a
Clone:
SR84
Conjugate:
Brilliant Violet 421
Gene Alias:
Integrin α1, Integrin alpha-1, ITGA1, ITA1, VLA-1, VLA1
Immunogen:
P-Selectin IgG1 Fusion
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Antigen: CD49a
Clone: SR84
Conjugate: Brilliant Violet 786
Gene Alias: Integrin α1, Integrin alpha-1, ITGA1, ITA1, VLA-1, VLA1
Immunogen: P-Selectin IgG1 Fusion
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Antigen:
CD49a
Clone:
SR84
Conjugate:
Brilliant Violet 786
Gene Alias:
Integrin α1, Integrin alpha-1, ITGA1, ITA1, VLA-1, VLA1
Immunogen:
P-Selectin IgG1 Fusion
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ