BDB742421
IL-21Receptor (CD360) Mouse anti-Human, Brilliant Violet 650, Clone: 17A12, BD Optibuild™
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB742421-Each-of-1 | In Stock | ₹ 49,306.00 |
BDB742421 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,306.00
GST (18%): ₹ 8,875.08
Total Price: ₹ 58,181.08
Antigen
IL-21Receptor (CD360)
Clone
17A12
Conjugate
Brilliant Violet 650
Gene Alias
Interleukin-21 receptor, CD360, NILR
Immunogen
Human IL-21R Transfected Cell Line
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification
Monoclonal
Concentration
0.2mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Description
- The 17A12 monoclonal antibody specifically binds to the IL-21 Receptor (IL-21R)
- The IL-21R, also known as CD360, is a 538 amino acid cytokine receptor with an extracellular domain consisting of one copy of the conserved WSXWS -containing cytokine-binding domain
- The IL-21 receptor combines with the common cytokine-receptor -chain to form a functional receptor complex for IL-21
- IL-21 is mainly produced by activated CD4+ T cells including T follicular helper (Tfh) cells
- IL-21R is preferentially expressed by B cells, T cells, NK cells, some populations of myeloid cells, keratinocytes, and dendritic cells
- Binding of its ligand, IL-21, in these cells results in the activation of the Jak/Stat signal transduction pathway
- The effects IL-21 ligand binding has pleiotropic actions such as augmenting the proliferation of T cells, driving of B cells into memory cells, terminally differentiating plasma cells and augmenting the activity of natural killer cells
- IL-21 receptor has anti-tumor activity and might have a role in the development of autoimmunity; it has been reported that the IL-21 receptor affects the homeostasis of regulatory T cells and it could enhance T cell-activated responses in human immune-inflammatory diseases
- The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon Brilliant™ Violet family of dyes
- This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 650nm
- BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20nm filter)
- Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors
- However, the spillover can be corrected through compensation as with any other dye combination
- BV650 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 650 nm
- Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors
- BV650 will have moderate spillover into the BD Horizon™ BV711 detector.
Compare Similar Items
Show Difference
Antigen: IL-21Receptor (CD360)
Clone: 17A12
Conjugate: Brilliant Violet 650
Gene Alias: Interleukin-21 receptor, CD360, NILR
Immunogen: Human IL-21R Transfected Cell Line
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Antigen:
IL-21Receptor (CD360)
Clone:
17A12
Conjugate:
Brilliant Violet 650
Gene Alias:
Interleukin-21 receptor, CD360, NILR
Immunogen:
Human IL-21R Transfected Cell Line
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Antigen: H-2Kd
Clone: SF1-1.1
Conjugate: Brilliant Violet 421
Gene Alias: H-2kd, H2kd, MHC class I H-2Kd
Immunogen: BALB/c Mouse Cells
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG2a κ
Antigen:
H-2Kd
Clone:
SF1-1.1
Conjugate:
Brilliant Violet 421
Gene Alias:
H-2kd, H2kd, MHC class I H-2Kd
Immunogen:
BALB/c Mouse Cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG2a κ
Antigen: H-2Kd
Clone: SF1-1.1
Conjugate: Brilliant Violet 510
Gene Alias: H-2kd, H2kd, MHC class I H-2Kd
Immunogen: BALB/c Mouse Cells
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG2a κ
Antigen:
H-2Kd
Clone:
SF1-1.1
Conjugate:
Brilliant Violet 510
Gene Alias:
H-2kd, H2kd, MHC class I H-2Kd
Immunogen:
BALB/c Mouse Cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG2a κ
Antigen: H-2Kd
Clone: SF1-1.1
Conjugate: Brilliant Violet 650
Gene Alias: H-2kd, H2kd, MHC class I H-2Kd
Immunogen: BALB/c Mouse Cells
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG2a κ
Antigen:
H-2Kd
Clone:
SF1-1.1
Conjugate:
Brilliant Violet 650
Gene Alias:
H-2kd, H2kd, MHC class I H-2Kd
Immunogen:
BALB/c Mouse Cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG2a κ