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BDB742543

CD365 (TIM-1) Mouse anti-Human, Brilliant Violet 711, Clone: 1D12, BD Optibuild™

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB742543-Each-of-1 In Stock ₹ 47,400.24

BDB742543 - Each of 1

₹ 47,400.24

In Stock

Quantity

1

Base Price: ₹ 47,400.24

GST (18%): ₹ 8,532.043

Total Price: ₹ 55,932.283

Antigen

CD365 (TIM-1)

Clone

1D12

Conjugate

Brilliant Violet 711

Gene Alias

CD365, TIM1, TIM, TIMD1, TIMD-1, HAVCR1, HAVCR-1, HAVCR, KIM1, KIM-1

Immunogen

Human TIM-1 Recombinant Protein

Quantity

50 μg

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Classification

Monoclonal

Concentration

0.2mg/mL

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Human

Isotype

IgG1 κ

Description

  • The 1D12 monoclonal antibody specifically binds to CD365, the T-cell immunoglobulin mucin receptor 1 (TIM-1)
  • TIM-1 is expressed on kidney epithelial cells, T cells, and some hematopoietic and non-hematopoietic cells
  • CD365 (TIM-1) is a type 1 transmembrane glycoprotein that serves as a receptor for hepatitis A virus and is encoded by the HAVCR1 /(Hepatitis A virus cellular receptor 1) gene
  • TIM-1 also serves as a receptor for phosphatidylserine which is exposed on the surface of apoptotic cells
  • TIM-1 can reportedly mediate the uptake of apoptotic cells through the recognition of phosphatidylserine and thus help maintain tissue homeostasis and self-tolerance
  • TIM-1 is likewise known as Kidney injury molecule 1 (KIM-1)
  • It is highly expressed by cancerous kidneys, and upregulated in the proximal tubular epithelium and shed into the urine during acute and chronic kidney injury
  • CD365 (TIM-1) also functions as a costimulatory molecule for immune cells
  • It is expressed by activated CD4+ T cells and regulates the effector functions (eg, enhanced cytokine production) and survival of differentiated T cells, including those mediating Th2-like immune responses
  • Other ligands have been described for TIM-1 including TIM-4 and LMIR5 (also known as CD300b) which are expressed by myeloid cells
  • With respect to disease associations, the HAVCR1 /gene has been linked to asthma, allergy, and some autoimmune diseases
  • The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes
  • This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 711nm
  • BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20nm filter)
  • Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors
  • However, the spillover can be corrected through compensation as with any other dye combination
  • BV711 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 711 nm
  • This dye offers a very bright choice for the violet laser
  • Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors
  • BV711 will also have moderate spillover into the BD Horizon Brilliant™ Violet 786 detector.

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Show Difference

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BD Biosciences

BDB742543

--

Antigen:
CD365 (TIM-1)
Clone:
1D12
Conjugate:
Brilliant Violet 711
Gene Alias:
CD365, TIM1, TIM, TIMD1, TIMD-1, HAVCR1, HAVCR-1, HAVCR, KIM1, KIM-1
Immunogen:
Human TIM-1 Recombinant Protein
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ

Img

BD Biosciences

BDB742545

--

Antigen:
CD365 (TIM-1)
Clone:
1D12
Conjugate:
Brilliant Ultraviolet 395
Gene Alias:
CD365, TIM1, TIM, TIMD1, TIMD-1, HAVCR1, HAVCR-1, HAVCR, KIM1, KIM-1
Immunogen:
Human TIM-1 Recombinant Protein
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ

Img

BD Biosciences

BDB742548

--

Antigen:
CD5
Clone:
L17F12
Conjugate:
Brilliant Violet 421
Gene Alias:
LEU1, Leu-1, Lymphocyte antigen T1, T1, LY1, Tp67
Immunogen:
Human T-cell acute lymphoblastic leukemia (T-ALL) cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ

Img

BD Biosciences

BDB742551

--

Antigen:
CD5
Clone:
L17F12
Conjugate:
Brilliant Violet 650
Gene Alias:
LEU1, Leu-1, Lymphocyte antigen T1, T1, LY1, Tp67
Immunogen:
Human T-cell acute lymphoblastic leukemia (T-ALL) cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ