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BDB743716

CD324 (E-Cadherin) Mouse anti-Human, Brilliant Violet 786, Clone: 67A4, BD Optibuild™

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB743716-Each-of-1 In Stock ₹ 47,400.24

BDB743716 - Each of 1

₹ 47,400.24

In Stock

Quantity

1

Base Price: ₹ 47,400.24

GST (18%): ₹ 8,532.043

Total Price: ₹ 55,932.283

Antigen

CD324 (E-Cadherin)

Clone

67A4

Conjugate

Brilliant Violet 786

Gene Alias

E-cadherin, CD324, CDH1, CADH1, Cadherin-1, ECAD, CDHE, Arc-1, LCAM, UVO

Immunogen

Human Breast Tumor Cell Line

Quantity

50 μg

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Classification

Monoclonal

Concentration

0.2mg/mL

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Human

Isotype

IgG1 κ

Description

  • The 67A4 monoclonal antibody specifically recognizes the extracellular domain of human E-Cadherin (CD324)
  • E-Cadherin is a 120-kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells
  • There it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins
  • In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation
  • Its association with catenins is necessary for cell-to-cell adhesion
  • These E-Cadherin/catenin complexes associate with cortical actin bundles at both the zonula adherens and the lateral adhesion plaques
  • Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties
  • E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas
  • Increased expression of E-Cadherin in these cells reduces their invasiveness
  • Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression
  • Pluripotent stem cells express E-Cadherin
  • Upon differentiation, an epithelial to mesenchymal transition results in the loss of E-cadherin expression and a gain in the expression of N-cadherin
  • The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes
  • This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 786nm
  • BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60nm filter)
  • BV786 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 786 nm
  • BV786 offers a bright choice for the 6th detector off the violet laser.

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Show Difference

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BD Biosciences

BDB743716

--

Antigen:
CD324 (E-Cadherin)
Clone:
67A4
Conjugate:
Brilliant Violet 786
Gene Alias:
E-cadherin, CD324, CDH1, CADH1, Cadherin-1, ECAD, CDHE, Arc-1, LCAM, UVO
Immunogen:
Human Breast Tumor Cell Line
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ

Img

BD Biosciences

BDB743720

--

Antigen:
CD253
Clone:
RIK-2
Conjugate:
Brilliant Violet 605
Gene Alias:
TNFSF10, TRAIL, APO-2L, TL2
Immunogen:
Human TRAIL Transfected Cell Line
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1

Img

BD Biosciences

BDB743721

--

Antigen:
CD253
Clone:
RIK-2
Conjugate:
Brilliant Violet 650
Gene Alias:
TNFSF10, TRAIL, APO-2L, TL2
Immunogen:
Human TRAIL Transfected Cell Line
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1

Img

BD Biosciences

BDB743723

--

Antigen:
CD253
Clone:
RIK-2
Conjugate:
Brilliant Violet 786
Gene Alias:
TNFSF10, TRAIL, APO-2L, TL2
Immunogen:
Human TRAIL Transfected Cell Line
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1