CD116 Mouse, anti-Human, R718, Clone: HGMCSFR-M1, BD OptiBuild™

Description

• The hGMCSFR-M1 antibody reacts with the subunit (GM-CSFR) of the human Granulocyte-Macrophage Colony-Stimulating Factor Receptor complex
• This 75-85 kD subunit is also known as CD116
• The hGMCSFR-M1 antibody was first clustered at the Fifth International Workshop on Human Leucocyte Differentiation Antigens
• The GM-CSFR subunit associates with the 120-140 kD βc subunit (common subunit, CD131), that is shared with the receptors for interleukins IL-3 and IL-5
• Both of the chains of the GM-CSFR complex are involved in ligand binding and intracellular signaling
• The α chain appears to transmit most of the biological signals
• CD116 is expressed by a variety of myeloid cell lines, hematopoietic and non-hematopoetic tumor cells, and normal cell types including monocytes, macrophages, neutrophils, eosinophils, myeloid dendritic cells, endothelial cells, fibroblasts, and placental trophoblasts
• Lymphocytes are negative for GM-CSFR expression
• Reports suggest that GM-CSFR plays a role in myeloid lineage growth and differentiation
• The immunogen used to generate the hGMCSFR-M1 hybridoma was recombinant human GM-CSFR.