IgE Rcptr Mouse, anti-Rat, R718, Clone: BC4, BD OptiBuild™

Description

• The BC4 antibody reacts with the high-affinity IgE Fc receptor (FcεRI) expressed in rat mast cells, basophils, and non-B non-T cells
• The rat FcεRI is expressed as a tetrameric molecule consisting of one α chain, one β chain, and two identical γ chains
• The BC4 antibody has been reported to detect all three chains of the FcεRI by immunoprecipitation
• In the rat model, the β chain (FcRβ) is required for cell-surface expression of the complete FcεRI
• This differs from the human FcεRI, which can be expressed in trimer (αγ2) or tetramer forms (βγ2)
• Furthermore, the FcRβ has been characterized as a potent signaling molecule capable of substantially amplifying Fc-mediated cellular responses
• The FcεRI functions to mediate cellular degranulation and the release of histamine, leukotrienes, and various cytokines and chemokines
• The structure, expression, function, and signaling mechanisms of the FcεRI have been reviewed.