Phospho-IRE1 alpha (Ser724) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEPA585738-Each-of-1 | In Stock | ₹ 39,785.40 |
FEPA585738 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,785.40
GST (18%): ₹ 7,161.372
Total Price: ₹ 46,946.772
Antigen
Phospho-IRE1 alpha (Ser724)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ERN1
Gene Alias
9030414B18Rik, AI225830, C85377, endoplasmic reticulum (ER) to nucleus signalling 1, endoplasmic reticulum to nucleus signaling 1, endoplasmic reticulum to nucleus signalling 1, endoplasmic reticulum-to-nucleus signaling 1, Endoribonuclease, ER to nucleus signalling 1, ERN1, FLJ30999, hIRE1p, inositol-requiring 1, inositol-requiring 1 alpha, inositol-requiring enzyme 1, inositol-requiring protein 1, IRE1, IRE1a, IRE1a antibody, Ire1alpha, Ire1-alpha, Ire1p, IRE1p antibody, MGC163277, MGC163279, protein kinase/endoribonuclease, RGD1559716, Serine/threonine-protein kinase, Serine/threonine-protein kinase/endoribonuclease IRE1, serine/threonine-protein kinase/endoribonuclease IRE1-like
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2081, 498013, 78943
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
O75460, Q9EQY0
Gene Symbols
ERN1
Immunogen
Carrier-protein conjugated synthetic peptide corresponding to residues around human IRE1 (phospho Ser724).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Related Products
Description
- Keep as concentrated solution
- Predicted reactivity: Mouse (100%), Rat (100%), Japanese Medaka (100%)
- Positive Control: Neuro2A, C8D30, NIH-3T3, C2C12, Rat2, HepG2, HepG2 (3uM Thapsigargin treatment for 12 hr)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- ERN1 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signaling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals
- ERN1 controls IRE1 proteolysis in mammalian cells
- ERN1 has a critical function in extraembryonic cells that is essential for fetal viability
- Specifically, IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator
- Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER
- Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER.
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Antigen: Phospho-IRE1 alpha (Ser724)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ERN1
Gene Alias: 9030414B18Rik, AI225830, C85377, endoplasmic reticulum (ER) to nucleus signalling 1, endoplasmic reticulum to nucleus signaling 1, endoplasmic reticulum to nucleus signalling 1, endoplasmic reticulum-to-nucleus signaling 1, Endoribonuclease, ER to nucleus signalling 1, ERN1, FLJ30999, hIRE1p, inositol-requiring 1, inositol-requiring 1 alpha, inositol-requiring enzyme 1, inositol-requiring protein 1, IRE1, IRE1a, IRE1a antibody, Ire1alpha, Ire1-alpha, Ire1p, IRE1p antibody, MGC163277, MGC163279, protein kinase/endoribonuclease, RGD1559716, Serine/threonine-protein kinase, Serine/threonine-protein kinase/endoribonuclease IRE1, serine/threonine-protein kinase/endoribonuclease IRE1-like
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 2081, 498013, 78943
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG
Applications: Western Blot
Concentration: 0.5 mg/mL
Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: O75460, Q9EQY0
Gene Symbols: ERN1
Immunogen: Carrier-protein conjugated synthetic peptide corresponding to residues around human IRE1 (phospho Ser724).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen: __
Classification: __
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Content And Storage: Upon receipt store at 4°C.
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Content And Storage: Storage: Upon receipt store at room temperature or 4°C. Product shipped at ambient temperature.
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Quantity: 4 x 500 mL
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Form: Liquid
