Complement C5a Monoclonal Antibody (C17/5), Invitrogen™

Description

• Specificity: GAU 025-05 reacts with human C5a/C5a (desArg) and cross-reacts with baboon C5a/C5a (desArg)
• Reactivity: For ELISA applications, recombinant C5a coated onto a microtiter well results in a strong reaction
• NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes
• This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge
• An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase
• The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components
• Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections
• Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.