HM1630R1
MUC-1 Ab-5 Hamster Monoclonal Antibody, Epredia™
Manufacturer: Fischer Scientific
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Antigen
MUC-1 Ab-5
Classification
Monoclonal
Conjugate
Unconjugated
Host Species
Hamster
Quantity
1 mL
Research Discipline
Cancer and Tumor Biology
Target Species
Human, Mouse
Isotype
IgG
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
MH1; same as CT2
Formulation
Ready-to-use for IHC (UVLP)
Immunogen
A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1
Regulatory Status
RUO
Primary or Secondary
Primary
Form
Prediluted
Description
- Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells
- It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases
- In normal mammary gland it is expressed in apical surface of glandular epithelium
- In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost
- Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kDa) and a smaller subunit (14-28kDa) noncovalently associated with each other
- Transgenic Muc1 has been shown to associate with all four erbB receptors and localize with erbB1 (EGFR) in lactating glands1
- Muc1 can act as a ligand for ICAM-1 on HUVEC cells; it can bind beta-catenin, GSK3beta and it associates with Grb2-SOS upon phosphorylation
- Host Species: Hamster Clone: MH1 (CT2) Isotype: IgG Species Reactivity: Human and Mouse
- Others not tested
- Epitope: aa 239-255 Immunogen: A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) from the cytoplasmic tail of MUC-1 Molecular Weight: 14-28kDa Positive Control: MCF-7 cells; Breast CA Cellular Localization: Cytoplasmic and membrane Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting Immunofluorescence Immunoprecipitation Flow Cytometry Note: USA: RUO; Int'l: RUO
Compare Similar Items
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Antigen: MUC-1 Ab-5
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Hamster
Quantity: 1 mL
Research Discipline: Cancer and Tumor Biology
Target Species: Human, Mouse
Isotype: IgG
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: MH1; same as CT2
Formulation: Ready-to-use for IHC (UVLP)
Immunogen: A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1
Regulatory Status: RUO
Primary or Secondary: Primary
Form: Prediluted
Antigen:
MUC-1 Ab-5
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Hamster
Quantity:
1 mL
Research Discipline:
Cancer and Tumor Biology
Target Species:
Human, Mouse
Isotype:
IgG
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
MH1; same as CT2
Formulation:
Ready-to-use for IHC (UVLP)
Immunogen:
A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1
Regulatory Status:
RUO
Primary or Secondary:
Primary
Form:
Prediluted
Antigen: MUC-1 Ab-5
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Hamster
Quantity: 7 mL
Research Discipline: Cancer and Tumor Biology
Target Species: Human, Mouse
Isotype: IgG
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: MH1; same as CT2
Formulation: __
Immunogen: A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1
Regulatory Status: RUO
Primary or Secondary: Primary
Form: Prediluted
Antigen:
MUC-1 Ab-5
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Hamster
Quantity:
7 mL
Research Discipline:
Cancer and Tumor Biology
Target Species:
Human, Mouse
Isotype:
IgG
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
MH1; same as CT2
Formulation:
__
Immunogen:
A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1
Regulatory Status:
RUO
Primary or Secondary:
Primary
Form:
Prediluted
Antigen: CD3e
Classification: Monoclonal
Conjugate: Alexa Fluor 488
Host Species: Syrian Hamster
Quantity: 1 mL
Research Discipline: __
Target Species: Mouse
Isotype: IgG
Applications: Flow Cytometry
Clone: 500A2
Formulation: PBS with BSA and 0.1% sodium azide
Immunogen: C6VL-BS cell lysate
Regulatory Status: RUO
Primary or Secondary: Primary
Form: Liquid
Antigen:
CD3e
Classification:
Monoclonal
Conjugate:
Alexa Fluor 488
Host Species:
Syrian Hamster
Quantity:
1 mL
Research Discipline:
__
Target Species:
Mouse
Isotype:
IgG
Applications:
Flow Cytometry
Clone:
500A2
Formulation:
PBS with BSA and 0.1% sodium azide
Immunogen:
C6VL-BS cell lysate
Regulatory Status:
RUO
Primary or Secondary:
Primary
Form:
Liquid
Antigen: CD154 (CD40 Ligand)
Classification: Monoclonal
Conjugate: PE
Host Species: Armenian Hamster
Quantity: 100 μg
Research Discipline: __
Target Species: Mouse
Isotype: IgG3
Applications: Flow Cytometry
Clone: MR1
Formulation: PBS with <0.1% sodium azide
Immunogen: Mouse CD154. from Activated mouse Th1 clone D1.6
Regulatory Status: RUO
Primary or Secondary: Primary
Form: Liquid
Antigen:
CD154 (CD40 Ligand)
Classification:
Monoclonal
Conjugate:
PE
Host Species:
Armenian Hamster
Quantity:
100 μg
Research Discipline:
__
Target Species:
Mouse
Isotype:
IgG3
Applications:
Flow Cytometry
Clone:
MR1
Formulation:
PBS with <0.1% sodium azide
Immunogen:
Mouse CD154. from Activated mouse Th1 clone D1.6
Regulatory Status:
RUO
Primary or Secondary:
Primary
Form:
Liquid