beta-2 Microglobulin Monoclonal Antibody (9-E10-C6), Invitrogen™

Description

• KSK 003-01-02 reacts with free as well as MHC class I associated b2-microglobulin from the genus Caiman
• KSK 003-01-02 has been successfully used in immunohistochemistry and Western blotting techniques
• KSK 003-01-02 is suitable for Western blotting, flow cytometry, immunoprecipitation, and affinity purification on caiman b2-microglobulin
• KSK 003-01-02 reacts with a non-polymorphic epitope on caiman b2-microglobulin
• NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I
• Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes
• Beta-2 microglobulin is also found in free form in the plasma
• The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure
• The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation
• Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells
• Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15
• A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia
• Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients
• Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.