MABF205925
NKp46 (CD335), Mouse anti-Human, Clone: 461-G1, Millipore Sigma™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF205925-Each-of-1 | In Stock | ₹ 17,067.51 |
MABF205925 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 17,067.51
GST (18%): ₹ 3,072.152
Total Price: ₹ 20,139.662
Antigen
NKp46 (CD335)
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
NCR1;LY94
Immunogen
Human IgG1 Fc-fused to a recombinant fragment corresponding to the first 100 amino acids from the extracellular domain of human NKp46.
Quantity
25 μg
Research Discipline
Inflammation & Immunology
Gene ID (Entrez)
NP_001138929
Target Species
Human
Form
Purified
Applications
ELISA, Flow Cytometry
Clone
461-G1
Dilution
Flow Cytometry Analysis: 4μg/mL from a representative lot detected NKp46 (CD335) in NK-92™ cells transfected with human NKp46 (Courtesy of Angel Porgador, Ph.D., Faculty of Health Sciences, Ben Gurion university of the Negev, Israel).ELISA Analysis: A representative lot detected NKp46 (CD335) in ELISA applications (Yossef, R., et. al. (2015). PLoS One. 10(2):e0118936).
Gene Alias
Natural cytotoxicity triggering receptor 1;Lymphocyte antigen 94 homolog;NK cell-activating receptor;Natural killer cell p46-related protein;NK-p46;hNKp46;CD335
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 461-G1 specifically recognizes whole human NKp46 and NKp46-D1, but does not recognize NKp46-D2. It targets an epitope with in the first 100 amino acids from the extracellular domain.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Anti-NKp46 (CD335), clone 461-G1, Cat
- No
- MABF2059, is a mouse monoclonal antibody that detects Natural cytotoxicity triggering receptor 1 and has been tested for use in ELISA and Flow Cytometry
- Natural cytotoxicity triggering receptor 1 (UniProt: O76036; also known as Lymphocyte antigen 94 homolog, NK cell-activating receptor, Natural killer cell p46-related protein, NK-p46, NKp46, hNKp46, CD335) is encoded by the NCR1 (also known as LY94) gene (Gene ID: 9437) in human
- NK-p46 is a single-pass type I membrane protein that belongs to the natural cytotoxicity receptor (NCR) family and serves as a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis and elimination of virus-infected cells
- It is considered as a primary activating receptor mediating NK cell antiviral function
- It is involved in the functional recognition of viral HA and hemagglutinin-neuraminidases
- NKp46 is shown to be predominantly expressed in the nasal lavage of patients infected with respiratory viruses, but not in normal healthy subjects
- Following the initiation of an NK-target cell interaction, NKp46 is reported to cluster at the cell membrane, specifically at the immune synapse where it mediates cytoskeletal rearrangement and cellular polarization
- Human NK-p46 is synthesized with a signal peptide of 21 amino acids, which is subsequently cleaved off
- The mature form has an extracellular domain (aa 22-258), a helical domain (aa 259-279), and a cytoplasmic domain (aa 280-304)
- It also has two Ig-like domains (aa 34-118 and 129-211) termed as D1 and D2
- Five different isoforms of NKp46 have been described that are produced by alternative splicing
- (Ref.: Shemer-Avni, Y., et al., (2017)
- Front
- Immunol
- 8 (Article 161); 1-10).
Compare Similar Items
Show Difference
Antigen: NKp46 (CD335)
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: NCR1;LY94
Immunogen: Human IgG1 Fc-fused to a recombinant fragment corresponding to the first 100 amino acids from the extracellular domain of human NKp46.
Quantity: 25 μg
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): NP_001138929
Target Species: Human
Form: Purified
Applications: ELISA, Flow Cytometry
Clone: 461-G1
Dilution: Flow Cytometry Analysis: 4μg/mL from a representative lot detected NKp46 (CD335) in NK-92™ cells transfected with human NKp46 (Courtesy of Angel Porgador, Ph.D., Faculty of Health Sciences, Ben Gurion university of the Negev, Israel).ELISA Analysis: A representative lot detected NKp46 (CD335) in ELISA applications (Yossef, R., et. al. (2015). PLoS One. 10(2):e0118936).
Gene Alias: Natural cytotoxicity triggering receptor 1;Lymphocyte antigen 94 homolog;NK cell-activating receptor;Natural killer cell p46-related protein;NK-p46;hNKp46;CD335
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 461-G1 specifically recognizes whole human NKp46 and NKp46-D1, but does not recognize NKp46-D2. It targets an epitope with in the first 100 amino acids from the extracellular domain.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
NKp46 (CD335)
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
NCR1;LY94
Immunogen:
Human IgG1 Fc-fused to a recombinant fragment corresponding to the first 100 amino acids from the extracellular domain of human NKp46.
Quantity:
25 μg
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
NP_001138929
Target Species:
Human
Form:
Purified
Applications:
ELISA, Flow Cytometry
Clone:
461-G1
Dilution:
Flow Cytometry Analysis: 4μg/mL from a representative lot detected NKp46 (CD335) in NK-92™ cells transfected with human NKp46 (Courtesy of Angel Porgador, Ph.D., Faculty of Health Sciences, Ben Gurion university of the Negev, Israel).ELISA Analysis: A representative lot detected NKp46 (CD335) in ELISA applications (Yossef, R., et. al. (2015). PLoS One. 10(2):e0118936).
Gene Alias:
Natural cytotoxicity triggering receptor 1;Lymphocyte antigen 94 homolog;NK cell-activating receptor;Natural killer cell p46-related protein;NK-p46;hNKp46;CD335
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 461-G1 specifically recognizes whole human NKp46 and NKp46-D1, but does not recognize NKp46-D2. It targets an epitope with in the first 100 amino acids from the extracellular domain.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: __
Classification: __
Conjugate: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Applications: __
Clone: __
Dilution: __
Gene Alias: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Isotype: __
Antigen:
__
Classification:
__
Conjugate:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
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Target Species:
__
Form:
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Applications:
__
Clone:
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Dilution:
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Gene Alias:
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Purification Method:
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Regulatory Status:
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Primary or Secondary:
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Test Specificity:
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Content And Storage:
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Isotype:
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Antigen: IL13R alpha 1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: Il13ra1;Il13r;Il13ra
Immunogen: Recombinant mouse Interleukin-13 receptor subunit alpha-1.
Quantity: 25 μg
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): __
Target Species: Mouse
Form: Purified
Applications: Flow Cytometry, Immunoprecipitation, Western Blot
Clone: __
Dilution: __
Gene Alias: Interleukin-13 receptor subunit alpha-1;IL-13 receptor subunit alpha-1;IL-13R subunit alpha-1;IL-13RA1;Interleukin-13-binding protein;Novel cytokine receptor 4;NR4;CD213a1.
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone IG3 detects Interleukin-13 receptor subunit alpha-1 in murine cells.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Antigen:
IL13R alpha 1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
Il13ra1;Il13r;Il13ra
Immunogen:
Recombinant mouse Interleukin-13 receptor subunit alpha-1.
Quantity:
25 μg
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
__
Target Species:
Mouse
Form:
Purified
Applications:
Flow Cytometry, Immunoprecipitation, Western Blot
Clone:
__
Dilution:
__
Gene Alias:
Interleukin-13 receptor subunit alpha-1;IL-13 receptor subunit alpha-1;IL-13R subunit alpha-1;IL-13RA1;Interleukin-13-binding protein;Novel cytokine receptor 4;NR4;CD213a1.
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone IG3 detects Interleukin-13 receptor subunit alpha-1 in murine cells.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1
Antigen: __
Classification: __
Conjugate: __
Formulation: __
Gene Symbols: __
Immunogen: __
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Gene ID (Entrez): __
Target Species: __
Form: __
Applications: __
Clone: __
Dilution: __
Gene Alias: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Isotype: __
Antigen:
__
Classification:
__
Conjugate:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Form:
__
Applications:
__
Clone:
__
Dilution:
__
Gene Alias:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
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Test Specificity:
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Content And Storage:
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Isotype:
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