MABN227625
Dab1, Rat anti-Mouse, Clone: 4E12, Millipore Sigma™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN227625-Each-of-1 | In Stock | ₹ 16,456.61 |
MABN227625 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
Dab1
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
Dab1
Immunogen
GST-tagged full-length recombinant murine Disabled homolog 1 expressed in E. coli.
Quantity
25 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_034144.1
Target Species
Mouse
Form
Purified
Applications
Immunohistochemistry, Immunoprecipitation, Western Blot
Clone
4E12
Dilution
Western Blotting Analysis: A representative lot detected Dab1 in Western Blotting applications (Onoune, A., et. al. (2014). Neurosci Res. 88:23-27; Nakamura, K., et. al. (2016). Neuroscience. 336:20-29).Immunoprecipitation Analysis: A 1:500 dilution from a representative lot immunoprecipitated Dab1 in cerebral cortex tissue lysate from P20 mouse (Courtesy of Prof. Mitsuharu Hattori, Nagoya City University).Immunohistochemistry Analysis: A representative lot detected Dab1 in Immunohistochemistry applications (Onoune, A., et. al. (2014). Neurosci Res. 88:23-27).
Gene Alias
Disabled homolog 1
Host Species
Rat
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 4E12 is a rat monoclonal antibody that detects murine Disabled homolog 1 (Dab1).
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Anti-Dab1, clone 4E12, Cat
- No
- MABN2276, is a highly specific rat monoclonal antibody that targets Disabled homolog 1 and has been tested in Immunohistochemistry, Immunoprecipitation, and Western Blotting
- Disabled homolog 1 (UniProt: P97318; also known as DAB1) is encoded by the Dab1 gene (Gene ID: 13131) in murine species
- Dab 1 is mainly expressed in the brain and serves as an adapter molecule involved in neural development where it is reported to direct the migration of cortical neurons past previously formed neurons to reach their proper layer
- It is a cytosolic protein that is shown to be essential component of the reelin signaling pathway
- It is shown to bind to the cytoplasmic tail of Reelin receptor, APO E receptor 2, and to LDL receptor
- Dab1 can be phosphorylated on Tyr198, Tyr220, and Tyr232 upon reelin induction in embryonic neurons
- It can also be phosphorylated on Ser524, but this phosphorylation is independent of reelin signaling
- Tyrosine phosphorylation of Dab1 by Src family tyrosine kinases is considered to be the most critical downstream event in Reelin signaling
- Dab1 contains a phosphotyrosine interaction domain (PID) (aa 36-189), which specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins
- Seven different isoforms of Dab1 have been identified that are generated via alternative splicing
- Clone 4E12 binds to an epitope within amino acids 161-320
- (Ref.: Onoue, A., et al
- (2014)
- Neurosci
- Res
- 88; 23-27).
Compare Similar Items
Show Difference
Antigen: Dab1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: Dab1
Immunogen: GST-tagged full-length recombinant murine Disabled homolog 1 expressed in E. coli.
Quantity: 25 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_034144.1
Target Species: Mouse
Form: Purified
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Clone: 4E12
Dilution: Western Blotting Analysis: A representative lot detected Dab1 in Western Blotting applications (Onoune, A., et. al. (2014). Neurosci Res. 88:23-27; Nakamura, K., et. al. (2016). Neuroscience. 336:20-29).Immunoprecipitation Analysis: A 1:500 dilution from a representative lot immunoprecipitated Dab1 in cerebral cortex tissue lysate from P20 mouse (Courtesy of Prof. Mitsuharu Hattori, Nagoya City University).Immunohistochemistry Analysis: A representative lot detected Dab1 in Immunohistochemistry applications (Onoune, A., et. al. (2014). Neurosci Res. 88:23-27).
Gene Alias: Disabled homolog 1
Host Species: Rat
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 4E12 is a rat monoclonal antibody that detects murine Disabled homolog 1 (Dab1).
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
Dab1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
Dab1
Immunogen:
GST-tagged full-length recombinant murine Disabled homolog 1 expressed in E. coli.
Quantity:
25 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_034144.1
Target Species:
Mouse
Form:
Purified
Applications:
Immunohistochemistry, Immunoprecipitation, Western Blot
Clone:
4E12
Dilution:
Western Blotting Analysis: A representative lot detected Dab1 in Western Blotting applications (Onoune, A., et. al. (2014). Neurosci Res. 88:23-27; Nakamura, K., et. al. (2016). Neuroscience. 336:20-29).Immunoprecipitation Analysis: A 1:500 dilution from a representative lot immunoprecipitated Dab1 in cerebral cortex tissue lysate from P20 mouse (Courtesy of Prof. Mitsuharu Hattori, Nagoya City University).Immunohistochemistry Analysis: A representative lot detected Dab1 in Immunohistochemistry applications (Onoune, A., et. al. (2014). Neurosci Res. 88:23-27).
Gene Alias:
Disabled homolog 1
Host Species:
Rat
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 4E12 is a rat monoclonal antibody that detects murine Disabled homolog 1 (Dab1).
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: FMR1polyG
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: __
Gene Symbols: FMR1
Immunogen: Ovalbumin-conjugated linear peptide with EAPLPGGVRQRGG sequence. Note: This protein is translated within the 5'UTR of the FMR1 gene and in a different frame resulting in a protein with different sequence and containing polyGlycine.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_002015
Target Species: Human
Form: Ascites
Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Clone: 8FM-2F7
Dilution: __
Gene Alias: __
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 8FM-2F7 specifically detects FMR1polyG in human cells.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG1 κ
Antigen:
FMR1polyG
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
FMR1
Immunogen:
Ovalbumin-conjugated linear peptide with EAPLPGGVRQRGG sequence. Note: This protein is translated within the 5'UTR of the FMR1 gene and in a different frame resulting in a protein with different sequence and containing polyGlycine.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_002015
Target Species:
Human
Form:
Ascites
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Clone:
8FM-2F7
Dilution:
__
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 8FM-2F7 specifically detects FMR1polyG in human cells.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG1 κ
Antigen: FMR1polyG
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: __
Gene Symbols: FMR1
Immunogen: Ovalbumin-conjugated linear peptide with EAPLPGGVRQRGG sequence. Note: This protein is translated within the 5'UTR of the FMR1 gene and in a different frame resulting in a protein with different sequence and containing polyGlycine.
Quantity: 25 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_002015
Target Species: Human
Form: Ascites
Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Clone: 8FM-2F7
Dilution: __
Gene Alias: __
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 8FM-2F7 specifically detects FMR1polyG in human cells.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG1 κ
Antigen:
FMR1polyG
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
FMR1
Immunogen:
Ovalbumin-conjugated linear peptide with EAPLPGGVRQRGG sequence. Note: This protein is translated within the 5'UTR of the FMR1 gene and in a different frame resulting in a protein with different sequence and containing polyGlycine.
Quantity:
25 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_002015
Target Species:
Human
Form:
Ascites
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Clone:
8FM-2F7
Dilution:
__
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 8FM-2F7 specifically detects FMR1polyG in human cells.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG1 κ
Antigen: __
Classification: __
Conjugate: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Applications: __
Clone: __
Dilution: __
Gene Alias: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Isotype: __
Antigen:
__
Classification:
__
Conjugate:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Form:
__
Applications:
__
Clone:
__
Dilution:
__
Gene Alias:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__