MABS199525
MT-ATP6, Mouse anti-Human, Clone: 1G7-1G2, Millipore Sigma™
Manufacturer: MilliporeSigma
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS199525-Each-of-1 | In Stock | ₹ 16,456.61 |
MABS199525 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
MT-ATP6
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG2b in HEPES-Buffered Saline (15 mM HEPES, 150 mM NaCl, pH 7.2) with 0.02% sodium azide.
Gene Symbols
MT-ATP6;ATP6;ATPASE6;MTATP6
Immunogen
A synthetic peptide corresponding to the N-terminus of human MT-ATP6.
Quantity
25 μg
Research Discipline
Signaling
Test Specificity
Clone 1G7-1G2 detects ATP synthase subunit a (MT-ATP6) in mitochondria isolated from human cells.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG2b κ
Applications
Western Blot
Clone
1G7-1G2
Dilution
Western Blotting Analysis: 0.5μg/mL from a representative lot detected MT-ATP6 in mitochondria from human neonatal dermal fibroblasts and mitochondria from human neonatal dermal fibroblasts depleted of mtDNA (Courtesy of Michael F. Marusich, Ph.D., mAbDx, Inc., Eugene, OR USA).
Gene Alias
ATP synthase subunit a;F-ATPase protein 6
Host Species
Mouse
Purification Method
Protein L
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Description
- Anti-MT-ATP6, clone 1G7-1G2, Cat
- No
- MABS1995, is a mouse monoclonal antibody that detects ATP synthase subunit a and has been tested for use in Western Blotting
- ATP synthase subunit a (UniProt: P00846; also known as F-ATPase protein 6) is encoded by the MT-ATP6 (also known as ATP6, ATPASE6, MTATP6) gene (Gene ID: 4508) in human
- F-ATPase Protein 6 is an inner mitochondrial membrane protein and is a component of Complex V, which produces ATP from ADP in the presence of proton gradient across the membrane
- F-type ATPases have 2 components, CF1 - the catalytic core - and CF0- the membrane proton channel
- The CF1 catalytic core contains five subunits: alpha3, beta3, gamma1, delta1, epsilon1 and CF0 has three main subunits known as a, b, and c
- Together they form a rotary motor
- During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation
- Defects in MT-ATP6 gene cause multiple mitochondrial diseases, such as Leber hereditary optic neuropathy (LHON), which is characterized by acute and subacute loss of central vision due to optic nerve dysfunction
- Some defects also lead to mitochondrial complex V deficiency that leads to neuropathy, ataxia, and hypertrophic cardiomyopathy.
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Antigen: MT-ATP6
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG2b in HEPES-Buffered Saline (15 mM HEPES, 150 mM NaCl, pH 7.2) with 0.02% sodium azide.
Gene Symbols: MT-ATP6;ATP6;ATPASE6;MTATP6
Immunogen: A synthetic peptide corresponding to the N-terminus of human MT-ATP6.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone 1G7-1G2 detects ATP synthase subunit a (MT-ATP6) in mitochondria isolated from human cells.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2b κ
Applications: Western Blot
Clone: 1G7-1G2
Dilution: Western Blotting Analysis: 0.5μg/mL from a representative lot detected MT-ATP6 in mitochondria from human neonatal dermal fibroblasts and mitochondria from human neonatal dermal fibroblasts depleted of mtDNA (Courtesy of Michael F. Marusich, Ph.D., mAbDx, Inc., Eugene, OR USA).
Gene Alias: ATP synthase subunit a;F-ATPase protein 6
Host Species: Mouse
Purification Method: Protein L
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
MT-ATP6
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG2b in HEPES-Buffered Saline (15 mM HEPES, 150 mM NaCl, pH 7.2) with 0.02% sodium azide.
Gene Symbols:
MT-ATP6;ATP6;ATPASE6;MTATP6
Immunogen:
A synthetic peptide corresponding to the N-terminus of human MT-ATP6.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone 1G7-1G2 detects ATP synthase subunit a (MT-ATP6) in mitochondria isolated from human cells.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2b κ
Applications:
Western Blot
Clone:
1G7-1G2
Dilution:
Western Blotting Analysis: 0.5μg/mL from a representative lot detected MT-ATP6 in mitochondria from human neonatal dermal fibroblasts and mitochondria from human neonatal dermal fibroblasts depleted of mtDNA (Courtesy of Michael F. Marusich, Ph.D., mAbDx, Inc., Eugene, OR USA).
Gene Alias:
ATP synthase subunit a;F-ATPase protein 6
Host Species:
Mouse
Purification Method:
Protein L
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: ST8SIA1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgM in PBS with 0.05% sodium azide.
Gene Symbols: ST8SIA1;SIAT8;SIAT8A
Immunogen: Trypsin-dissociated human pancreatic islet cells with low levels of exocrine and ductal cells.
Quantity: 100 μg
Research Discipline: Signaling
Test Specificity: Clone HIC0-3C5 specifically detects human Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1).
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgM κ
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry
Clone: HIC0-3C5
Dilution: Flow Cytometry Analysis: A representative lot detected ST8SIA1 in Flow Cytometry applications (Dorrell, C., et. al. (2016). Nat Commun. 7:11756).Immunofluorescence Analysis: A representative lot detected ST8SIA1 in Immunofluorescence applications (Dorrell, C., et. al. (2016). Nat Commun. 7:11756).
Gene Alias: Alpha-N-acetylneuraminide alpha-2;8-sialyltransferase;EC: 2.4.99.8;Alpha-2;8-sialyltransferase 8A;Ganglioside GD3 synthase;Ganglioside GT3 synthase;Sialyltransferase 8A;SIAT8-A;Sialyltransferase St8Sia I;ST8SiaI
Host Species: Mouse
Purification Method: Purified by ion-exchange chromatography
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
ST8SIA1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgM in PBS with 0.05% sodium azide.
Gene Symbols:
ST8SIA1;SIAT8;SIAT8A
Immunogen:
Trypsin-dissociated human pancreatic islet cells with low levels of exocrine and ductal cells.
Quantity:
100 μg
Research Discipline:
Signaling
Test Specificity:
Clone HIC0-3C5 specifically detects human Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1).
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgM κ
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry
Clone:
HIC0-3C5
Dilution:
Flow Cytometry Analysis: A representative lot detected ST8SIA1 in Flow Cytometry applications (Dorrell, C., et. al. (2016). Nat Commun. 7:11756).Immunofluorescence Analysis: A representative lot detected ST8SIA1 in Immunofluorescence applications (Dorrell, C., et. al. (2016). Nat Commun. 7:11756).
Gene Alias:
Alpha-N-acetylneuraminide alpha-2;8-sialyltransferase;EC: 2.4.99.8;Alpha-2;8-sialyltransferase 8A;Ganglioside GD3 synthase;Ganglioside GT3 synthase;Sialyltransferase 8A;SIAT8-A;Sialyltransferase St8Sia I;ST8SiaI
Host Species:
Mouse
Purification Method:
Purified by ion-exchange chromatography
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: ST8SIA1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgM in PBS with 0.05% sodium azide.
Gene Symbols: ST8SIA1;SIAT8;SIAT8A
Immunogen: Trypsin-dissociated human pancreatic islet cells with low levels of exocrine and ductal cells.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone HIC0-3C5 specifically detects human Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1).
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgM κ
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry
Clone: HIC0-3C5
Dilution: Flow Cytometry Analysis: A representative lot detected ST8SIA1 in Flow Cytometry applications (Dorrell, C., et. al. (2016). Nat Commun. 7:11756).Immunofluorescence Analysis: A representative lot detected ST8SIA1 in Immunofluorescence applications (Dorrell, C., et. al. (2016). Nat Commun. 7:11756).
Gene Alias: Alpha-N-acetylneuraminide alpha-2;8-sialyltransferase;EC: 2.4.99.8;Alpha-2;8-sialyltransferase 8A;Ganglioside GD3 synthase;Ganglioside GT3 synthase;Sialyltransferase 8A;SIAT8-A;Sialyltransferase St8Sia I;ST8SiaI
Host Species: Mouse
Purification Method: Purified by ion-exchange chromatography
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
ST8SIA1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgM in PBS with 0.05% sodium azide.
Gene Symbols:
ST8SIA1;SIAT8;SIAT8A
Immunogen:
Trypsin-dissociated human pancreatic islet cells with low levels of exocrine and ductal cells.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone HIC0-3C5 specifically detects human Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1).
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgM κ
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry
Clone:
HIC0-3C5
Dilution:
Flow Cytometry Analysis: A representative lot detected ST8SIA1 in Flow Cytometry applications (Dorrell, C., et. al. (2016). Nat Commun. 7:11756).Immunofluorescence Analysis: A representative lot detected ST8SIA1 in Immunofluorescence applications (Dorrell, C., et. al. (2016). Nat Commun. 7:11756).
Gene Alias:
Alpha-N-acetylneuraminide alpha-2;8-sialyltransferase;EC: 2.4.99.8;Alpha-2;8-sialyltransferase 8A;Ganglioside GD3 synthase;Ganglioside GT3 synthase;Sialyltransferase 8A;SIAT8-A;Sialyltransferase St8Sia I;ST8SiaI
Host Species:
Mouse
Purification Method:
Purified by ion-exchange chromatography
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
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Classification: __
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