Synuclein Ab-2 Mouse Monoclonal Antibody, Epredia™

Description

• Synnuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals
• In vertebrates they are encoded by three different genes
• Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's (PD) and breast cancer
• In AD, a peptide derived from α-synuclein forms an intrinsic component of plaque amyloid
• In PD, an alpha synuclein accumulates in Lewy bodies
• An allele of α synuclein has been linked to many familial cases of PD
• In breast cancer increased expression of γ synuclein correlates with the disease progression
• Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds
• Host Species: Mouse Clone: syn211 Isotype: IgG1 Species Reactivity: Human
• Does not react with mouse and rat
• Others not known
• Epitope: Not determined Immunogen: Human recombinant α-synuclein Molecular Weight: ∽14kDa Positive Control: Brain Cellular Localization: Neuronal cytosol and presynaptic terminals Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting Immunoprecipitation Note: USA: RUO; Int'l: RUO