Transglutaminase II Ab-1 Mouse Monoclonal Antibody, Epredia™

Description

• Transglutaminase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains
• It is also known as TGC, tTG, type II-, Gh, cytosolic-, liver-, endothelial-, erythrocyte-, cellular-transglutaminase
• Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions
• It is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing
• Host Species: Mouse Clone: CUB 7402 Isotype: IgG1/κ Species Reactivity: Human, Dog, Rabbit and Guinea Pig
• Does not react with mouse and rat
• Others not known
• Epitope: aa 447-478 Immunogen: Purified guinea pig liver TGase II Molecular Weight: 77-85kDa Positive Control: HUVEC cells, Breast CA Cellular Localization: Cytoplasm, membrane and extracellular matrix Ab-1 inhibits the TGase II activity
• Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting Immunofluorescence Immunoprecipitation (Native and denatured) Affinity Purification Biological Blockade Note: USA: RUO; Int'l: RUO