CD137 (4-1BB) Ab-1 Mouse Monoclonal Antibody, Epredia™

Description

• 4-1BB (also known as CD137) is an inducible receptor-like protein expressed on the cell surface of activated splenic T cells and thymocytes
• It exists as both a monomer and a dimer on the surface of activated T cells
• 4-1BB is structurally related to the members of NGFR/TNFR superfamily which are characterized by the presence of three-six patterns of a cysteine-rich motif in their extracellular domains
• Other members of this family include low affinity NGFR, two receptors for TNF (TNFR-I & TNFR-II), CD30, CD40, OX40, Fas, and CD27
• These molecules are involved in cell growth, survival, and death processes
• The cytoplasmic domain of 4-1BB include two runs of acidic amino acids, a potential p56 lck binding site, five consecutive glycines at the C-terminus, and four potential phosphorylation sites: one tyrosine, two threonine, and one serine
• Host Species: Mouse Clone: BBK-2 Isotype: IgG1/κ Species Reactivity: Human
• Others not known
• Epitope: Ectodomain Immunogen: Ectodomain of human 4-1BB recombinant protein Molecular Weight: 30kDa Positive Control: Spleen, thymus or tonsil Cellular Localization: Membrane Recommended for: Immunofluorescence Flow Cytometry Note: USA: RUO; Int'l: RUO