Epredia™ Lab Vision™ CD38 Ab-3, Mouse Monoclonal Antibody

Description

• CD38 is a single chain type II integral transmembrane protein, which is highly expressed on thymocytes
• It is also present on activated T cells and terminally differentiated B cells (plasma cells)
• Other reactive cells include NK cells, monocytes, macrophages, and dendritic cells
• CD38 may be detected on cells from multiple myeloma, ALL (B and T) and some AML
• It is, however, not found on most mature resting peripheral lymphocytes
• CD38 functions as a multicatalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor
• Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e
• identification of myelomas), and as a marker for activated B and T cells
• Host Species: Mouse Clone: 38C03; same as SPC32 Isotype: IgG1 Species Reactivity: Human
• Others not tested
• Epitope: Extracellular Immunogen: Recombinant protein encoding the extracellular domain of human CD38 Molecular Weight: 45 kDa Positive Control: Tonsil Cellular Localization: Membrane Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting (Not suitable) Note: USA: RUO; Int'l: RUO