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NB018511

P2X7/P2RX7 Antibody (Hano43) - BSA Free, Novus Biologicals™

Manufacturer: Fischer Scientific

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Pack Size SKU Availability Price
Each of 1 NB018511-Each-of-1 In Stock ₹ 17,668.14

NB018511 - Each of 1

₹ 17,668.14

In Stock

Quantity

1

Base Price: ₹ 17,668.14

GST (18%): ₹ 3,180.265

Total Price: ₹ 20,848.405

Antigen

P2X7/P2RX7

Classification

Monoclonal

Concentration

1 mg/mL

Dilution

Flow Cytometry 1:25-1:200, Immunocytochemistry/Immunofluorescence 1:10-1:2000

Gene Accession No.

Q9Z1M0

Gene Symbols

P2RX7

Immunogen

A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.

Quantity

0.025 mg

Primary or Secondary

Primary

Test Specificity

This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.

Content And Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Isotype

IgG2b

Applications

Immunocytochemistry, Flow Cytometry, Immunofluorescence

Clone

Hano43

Conjugate

Unconjugated

Formulation

PBS (pH 7.4) with 0.09% Sodium Azide

Gene Alias

ATP receptor, MGC20089, P2X purinoceptor 7, P2X7P2X7 receptor, P2X7R, P2Z receptor, Purinergic receptor, purinergic receptor P2X, ligand-gated ion channel, 7, purinergic receptor P2X7 variant A

Host Species

Rat

Purification Method

Protein G purified

Regulatory Status

RUO

Gene ID (Entrez)

5027

Target Species

Mouse

Form

Purified

Description

  • Description P2X7/P2RX7 Monoclonal specifically detects P2X7/P2RX7 in Mouse samples
  • It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence.

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Fischer Scientific

NB018511

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Antigen:
P2X7/P2RX7
Classification:
Monoclonal
Concentration:
1 mg/mL
Dilution:
Flow Cytometry 1:25-1:200, Immunocytochemistry/Immunofluorescence 1:10-1:2000
Gene Accession No.:
Q9Z1M0
Gene Symbols:
P2RX7
Immunogen:
A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
Quantity:
0.025 mg
Primary or Secondary:
Primary
Test Specificity:
This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgG2b
Applications:
Immunocytochemistry, Flow Cytometry, Immunofluorescence
Clone:
Hano43
Conjugate:
Unconjugated
Formulation:
PBS (pH 7.4) with 0.09% Sodium Azide
Gene Alias:
ATP receptor, MGC20089, P2X purinoceptor 7, P2X7P2X7 receptor, P2X7R, P2Z receptor, Purinergic receptor, purinergic receptor P2X, ligand-gated ion channel, 7, purinergic receptor P2X7 variant A
Host Species:
Rat
Purification Method:
Protein G purified
Regulatory Status:
RUO
Gene ID (Entrez):
5027
Target Species:
Mouse
Form:
Purified

Img

Fischer Scientific

NB018513

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Antigen:
TRAIL/TNFSF10
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Dilution:
Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, Functional, CyTOF-ready
Gene Accession No.:
P50591
Gene Symbols:
TNFSF10
Immunogen:
Recombinant human CD253 (TRAIL) aa 95-281.
Quantity:
0.05 mg
Primary or Secondary:
Primary
Test Specificity:
This antibody recognises the 281 amino acid protein termed TNF related apoptosis-inducing ligand (TRAIL), also known as CD253.
Content And Storage:
Store at -20C. Avoid freeze-thaw cycles.
Isotype:
IgG1
Applications:
Functional Assay, Flow Cytometry, Western Blot, CyTOF
Clone:
200000
Conjugate:
Unconjugated
Formulation:
PBS with No Preservative
Gene Alias:
Apo-2 ligand, APO2L, Apo-2Ltumor necrosis factor (ligand) family, member 10, APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta, CD253, CD253 antigen, Protein TRAIL, TL2, TNF-related apoptosis-inducing ligand, TRAILTNF-related apoptosis inducing ligand TRAIL, tumor necrosis factor (ligand) superfamily, member 10, tumor necrosis factor ligand superfamily member 10
Host Species:
Mouse
Purification Method:
Protein A purified
Regulatory Status:
RUO
Gene ID (Entrez):
8743
Target Species:
Human
Form:
Purified

Img

Fischer Scientific

NB018516

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Antigen:
CYBB/NOX2
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Dilution:
Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen 1:10-1:500
Gene Accession No.:
P04839
Gene Symbols:
CYBB
Immunogen:
Cytochrome B245 solubilised in octyl-beta-glucopyranoside
Quantity:
0.025 mg
Primary or Secondary:
Primary
Test Specificity:
This antibody recognises the heavy chain of cytochrome B245. It recognises the native as well as the denatured form of the protein
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgG1
Applications:
Immunohistochemistry, Flow Cytometry, Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, ELISA, Immunocytochemistry
Clone:
NL7
Conjugate:
Unconjugated
Formulation:
PBS (pH 7.4) with 0.09% Sodium Azide
Gene Alias:
CGD, CGD91-phox, Cytochrome b(558) subunit beta, cytochrome b-245 heavy chain, cytochrome b-245, beta polypeptide, Cytochrome b558 subunit beta, EC 1.6.3, GP91-1, GP91PHOX, GP91-PHOX, Heme-binding membrane glycoprotein gp91phox, NADPH oxidase 2, Neutrophil cytochrome b 91 kDa polypeptide, NOX2chronic granulomatous disease, p22 phagocyte B-cytochrome, p91-PHOX, Superoxide-generating NADPH oxidase heavy chain subunit
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Gene ID (Entrez):
1536
Target Species:
Human
Form:
Purified

Img

Fischer Scientific

NB018521

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Antigen:
Perforin
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Dilution:
Western Blot 1:100-1:2000
Gene Accession No.:
__
Gene Symbols:
PRF1
Immunogen:
The immunogen for this antibody was Perforin.
Quantity:
25 μg
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Store at 4C. Do not freeze.
Isotype:
IgG2b
Applications:
Western Blot
Clone:
BOR21
Conjugate:
Unconjugated
Formulation:
Aqueous, may contain carrier protein/stabilizer. with 0.09% Sodium Azide
Gene Alias:
Cytolysin, FLH2, HPLH2, HPLH2lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1PFN1, perforin 1 (pore forming protein), perforin-1, PFPcytolysin
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Gene ID (Entrez):
5551
Target Species:
Human
Form:
__