NB10064340
Complement C8A/B/G Antibody (056B-373) - BSA Free, Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NB10064340-Each-of-1 | In Stock | ₹ 42,737.22 |
NB10064340 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,737.22
GST (18%): ₹ 7,692.70
Total Price: ₹ 50,429.92
Antigen
Complement C8A/B/G
Classification
Monoclonal
Concentration
1.0 mg/mL
Dilution
Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Gene Alias
complement component 8, alpha polypeptide, complement component C8 alpha chain
Host Species
Mouse
Purification Method
Protein A purified
Regulatory Status
RUO
Gene ID (Entrez)
731
Target Species
Human
Form
Purified
Applications
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry (Frozen)
Clone
056B-373
Conjugate
Unconjugated
Gene Accession No.
P07360
Gene Symbols
C8A
Immunogen
Purified human C8
Quantity
0.05 mg
Primary or Secondary
Primary
Test Specificity
This antibody recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyzes the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
Content And Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype
IgG1
Related Products
Description
- Complement C8A/B/G Monoclonal specifically detects Complement C8A/B/G in Human samples
- It is validated for Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry-Frozen.
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Antigen: Complement C8A/B/G
Classification: Monoclonal
Concentration: 1.0 mg/mL
Dilution: Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Gene Alias: complement component 8, alpha polypeptide, complement component C8 alpha chain
Host Species: Mouse
Purification Method: Protein A purified
Regulatory Status: RUO
Gene ID (Entrez): 731
Target Species: Human
Form: Purified
Applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry (Frozen)
Clone: 056B-373
Conjugate: Unconjugated
Gene Accession No.: P07360
Gene Symbols: C8A
Immunogen: Purified human C8
Quantity: 0.05 mg
Primary or Secondary: Primary
Test Specificity: This antibody recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyzes the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype: IgG1
Antigen:
Complement C8A/B/G
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Dilution:
Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Gene Alias:
complement component 8, alpha polypeptide, complement component C8 alpha chain
Host Species:
Mouse
Purification Method:
Protein A purified
Regulatory Status:
RUO
Gene ID (Entrez):
731
Target Species:
Human
Form:
Purified
Applications:
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry (Frozen)
Clone:
056B-373
Conjugate:
Unconjugated
Gene Accession No.:
P07360
Gene Symbols:
C8A
Immunogen:
Purified human C8
Quantity:
0.05 mg
Primary or Secondary:
Primary
Test Specificity:
This antibody recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyzes the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgG1
Antigen: Complement Factor B
Classification: Monoclonal
Concentration: 1.0 mg/mL
Dilution: Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Gene Alias: BF AHUS4, B-factor, properdin, BFD, C3 proaccelerator, C3 proactivator, C3/C5 convertase, complement factor B, EC 3.4.21, EC 3.4.21.47, FB, FBI12, GBGCFAB, Glycine-rich beta glycoprotein, glycine-rich beta-glycoprotein, H2-Bf, PBF2, Properdin factor B
Host Species: Mouse
Purification Method: Protein A purified
Regulatory Status: RUO
Gene ID (Entrez): 629
Target Species: Human
Form: Purified
Applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry (Frozen)
Clone: 43382
Conjugate: Unconjugated
Gene Accession No.: P00751
Gene Symbols: CFB
Immunogen: Human factor B
Quantity: 0.05 mg
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype: IgG1
Antigen:
Complement Factor B
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Dilution:
Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Gene Alias:
BF AHUS4, B-factor, properdin, BFD, C3 proaccelerator, C3 proactivator, C3/C5 convertase, complement factor B, EC 3.4.21, EC 3.4.21.47, FB, FBI12, GBGCFAB, Glycine-rich beta glycoprotein, glycine-rich beta-glycoprotein, H2-Bf, PBF2, Properdin factor B
Host Species:
Mouse
Purification Method:
Protein A purified
Regulatory Status:
RUO
Gene ID (Entrez):
629
Target Species:
Human
Form:
Purified
Applications:
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry (Frozen)
Clone:
43382
Conjugate:
Unconjugated
Gene Accession No.:
P00751
Gene Symbols:
CFB
Immunogen:
Human factor B
Quantity:
0.05 mg
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgG1
Antigen: Complement Factor B
Classification: Monoclonal
Concentration: 1 mg/mL
Dilution: Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500, Functional
Gene Alias: BF AHUS4, B-factor, properdin, BFD, C3 proaccelerator, C3 proactivator, C3/C5 convertase, complement factor B, EC 3.4.21, EC 3.4.21.47, FB, FBI12, GBGCFAB, Glycine-rich beta glycoprotein, glycine-rich beta-glycoprotein, H2-Bf, PBF2, Properdin factor B
Host Species: Mouse
Purification Method: Protein A purified
Regulatory Status: RUO
Gene ID (Entrez): 629
Target Species: Human
Form: Purified
Applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry (Frozen), Functional Assay
Clone: 014III-33.2.4.3
Conjugate: Unconjugated
Gene Accession No.: P00751
Gene Symbols: CFB
Immunogen: Purified human complement factor b
Quantity: 0.05 mg
Primary or Secondary: Primary
Test Specificity: NB100-64343 recognizes the 30kDa Ba fragment of 90kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit), leaving the 63 kDa Bb subunit associated with C3b, forming C3 convertase. Subunit Ba inhibits lymphocyte proliferation. Conversely, subunit Bb is involved in the proliferation of preactivated B lymphocytes. NB100-64343 inhibits the function of factor B and binds both nascent factor B and the Ba cleavage product. Removal of Sodium Azide is recommended prior to use in functional assays.
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype: IgG1
Antigen:
Complement Factor B
Classification:
Monoclonal
Concentration:
1 mg/mL
Dilution:
Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500, Functional
Gene Alias:
BF AHUS4, B-factor, properdin, BFD, C3 proaccelerator, C3 proactivator, C3/C5 convertase, complement factor B, EC 3.4.21, EC 3.4.21.47, FB, FBI12, GBGCFAB, Glycine-rich beta glycoprotein, glycine-rich beta-glycoprotein, H2-Bf, PBF2, Properdin factor B
Host Species:
Mouse
Purification Method:
Protein A purified
Regulatory Status:
RUO
Gene ID (Entrez):
629
Target Species:
Human
Form:
Purified
Applications:
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry (Frozen), Functional Assay
Clone:
014III-33.2.4.3
Conjugate:
Unconjugated
Gene Accession No.:
P00751
Gene Symbols:
CFB
Immunogen:
Purified human complement factor b
Quantity:
0.05 mg
Primary or Secondary:
Primary
Test Specificity:
NB100-64343 recognizes the 30kDa Ba fragment of 90kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit), leaving the 63 kDa Bb subunit associated with C3b, forming C3 convertase. Subunit Ba inhibits lymphocyte proliferation. Conversely, subunit Bb is involved in the proliferation of preactivated B lymphocytes. NB100-64343 inhibits the function of factor B and binds both nascent factor B and the Ba cleavage product. Removal of Sodium Azide is recommended prior to use in functional assays.
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgG1
Antigen: Fc gamma RIIIA/CD16a
Classification: Monoclonal
Concentration: 1.0 mg/mL
Dilution: Flow Cytometry 1:10-1:1000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Gene Alias: CD16a, CD16a antigen, CD16FCRIIIA, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), Fc fragment of IgG, low affinity IIIa, receptor for (CD16), Fc gamma receptor III-A, FCG3, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD16), Fc-gamma RIII, Fc-gamma RIIIa, Fc-gamma RIII-alpha, FCGR3, FCGRIII, FCR-10, FcRIII, FcRIIIa, IGFR3FcgammaRIIIA, immunoglobulin G Fc receptor III, low affinity III, receptor for (CD16), low affinity immunoglobulin gamma Fc region receptor III-A, neutrophil-specific antigen NA
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Gene ID (Entrez): 2214
Target Species: Human
Form: Purified
Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clone: DJ130c
Conjugate: Unconjugated
Gene Accession No.: P08637
Gene Symbols: FCGR3A
Immunogen: CD34 antigen
Quantity: 0.1 mg
Primary or Secondary: Primary
Test Specificity: NB100-64346 recognizes human CD16, a 50-65kD cell surface molecule, which is the low affinity receptor for IgG (FcR III). CD16 exists as a transmembranous form (Fc gammaRIIIA, or CD16A) and a glycosyl phosphatidylinositol (GPI) anchored form (Fc gammaRIIIB, or CD16B). CD16A is expressed by NK cells, some T cells, and macrophages, whereas CD16B is primarily expressed by granulocytes. In addition, CD16B exists as two allelic variants NA1 and NA2. DJ130c recognizes all polymorphonuclear cells irrespective on their NA phenotype. Studies show that the DJ130c antibody recognizes an epitope in the first membrane-distal domain of CD16 and recognizes both CD16A and CD16B.
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype: IgG1
Antigen:
Fc gamma RIIIA/CD16a
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Dilution:
Flow Cytometry 1:10-1:1000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Gene Alias:
CD16a, CD16a antigen, CD16FCRIIIA, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), Fc fragment of IgG, low affinity IIIa, receptor for (CD16), Fc gamma receptor III-A, FCG3, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD16), Fc-gamma RIII, Fc-gamma RIIIa, Fc-gamma RIII-alpha, FCGR3, FCGRIII, FCR-10, FcRIII, FcRIIIa, IGFR3FcgammaRIIIA, immunoglobulin G Fc receptor III, low affinity III, receptor for (CD16), low affinity immunoglobulin gamma Fc region receptor III-A, neutrophil-specific antigen NA
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Gene ID (Entrez):
2214
Target Species:
Human
Form:
Purified
Applications:
Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clone:
DJ130c
Conjugate:
Unconjugated
Gene Accession No.:
P08637
Gene Symbols:
FCGR3A
Immunogen:
CD34 antigen
Quantity:
0.1 mg
Primary or Secondary:
Primary
Test Specificity:
NB100-64346 recognizes human CD16, a 50-65kD cell surface molecule, which is the low affinity receptor for IgG (FcR III). CD16 exists as a transmembranous form (Fc gammaRIIIA, or CD16A) and a glycosyl phosphatidylinositol (GPI) anchored form (Fc gammaRIIIB, or CD16B). CD16A is expressed by NK cells, some T cells, and macrophages, whereas CD16B is primarily expressed by granulocytes. In addition, CD16B exists as two allelic variants NA1 and NA2. DJ130c recognizes all polymorphonuclear cells irrespective on their NA phenotype. Studies show that the DJ130c antibody recognizes an epitope in the first membrane-distal domain of CD16 and recognizes both CD16A and CD16B.
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgG1