NB254365200
Filaggrin Antibody (SPM181) - Azide and BSA Free, Novus Biologicals™
Manufacturer: Fischer Scientific
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Antigen
Filaggrin
Classification
Monoclonal
Concentration
1 mg/mL
Dilution
Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Gene Alias
ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
Host Species
Mouse
Purification Method
Protein A or G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Content And Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Isotype
IgG1 κ
Applications
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Clone
SPM181
Conjugate
Unconjugated
Formulation
PBS with No Preservative
Gene Symbols
FLG
Immunogen
Recombinant human Filaggrin protein
Quantity
200 μg
Research Discipline
Cytoskeleton Markers
Gene ID (Entrez)
2312
Target Species
Human
Form
Purified
Related Products
Description
- Filaggrin Monoclonal specifically detects Filaggrin in Human samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
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Antigen: Filaggrin
Classification: Monoclonal
Concentration: 1 mg/mL
Dilution: Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Gene Alias: ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Content And Storage: Store at -20 to -80C. Avoid freeze-thaw cycles.
Isotype: IgG1 κ
Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Clone: SPM181
Conjugate: Unconjugated
Formulation: PBS with No Preservative
Gene Symbols: FLG
Immunogen: Recombinant human Filaggrin protein
Quantity: 200 μg
Research Discipline: Cytoskeleton Markers
Gene ID (Entrez): 2312
Target Species: Human
Form: Purified
Antigen:
Filaggrin
Classification:
Monoclonal
Concentration:
1 mg/mL
Dilution:
Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Gene Alias:
ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Content And Storage:
Store at -20 to -80C. Avoid freeze-thaw cycles.
Isotype:
IgG1 κ
Applications:
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Clone:
SPM181
Conjugate:
Unconjugated
Formulation:
PBS with No Preservative
Gene Symbols:
FLG
Immunogen:
Recombinant human Filaggrin protein
Quantity:
200 μg
Research Discipline:
Cytoskeleton Markers
Gene ID (Entrez):
2312
Target Species:
Human
Form:
Purified
Antigen: Filaggrin
Classification: Monoclonal
Concentration: 1 mg/mL
Dilution: Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Gene Alias: ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery
Content And Storage: Store at -20 to -80C. Avoid freeze-thaw cycles.
Isotype: IgG1
Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Clone: FLG/1561
Conjugate: Unconjugated
Formulation: PBS with No Preservative
Gene Symbols: FLG
Immunogen: Recombinant human Filaggrin protein fragment (aa 198-288) (exact sequence is proprietary)
Quantity: 100 μg
Research Discipline: Cytoskeleton Markers
Gene ID (Entrez): 2312
Target Species: Human
Form: Purified
Antigen:
Filaggrin
Classification:
Monoclonal
Concentration:
1 mg/mL
Dilution:
Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Gene Alias:
ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery
Content And Storage:
Store at -20 to -80C. Avoid freeze-thaw cycles.
Isotype:
IgG1
Applications:
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Clone:
FLG/1561
Conjugate:
Unconjugated
Formulation:
PBS with No Preservative
Gene Symbols:
FLG
Immunogen:
Recombinant human Filaggrin protein fragment (aa 198-288) (exact sequence is proprietary)
Quantity:
100 μg
Research Discipline:
Cytoskeleton Markers
Gene ID (Entrez):
2312
Target Species:
Human
Form:
Purified
Antigen: Filaggrin
Classification: Monoclonal
Concentration: 1 mg/mL
Dilution: Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Gene Alias: ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery
Content And Storage: Store at -20 to -80C. Avoid freeze-thaw cycles.
Isotype: IgG1
Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Clone: FLG/1561
Conjugate: Unconjugated
Formulation: PBS with No Preservative
Gene Symbols: FLG
Immunogen: Recombinant human Filaggrin protein fragment (aa 198-288) (exact sequence is proprietary)
Quantity: 200 μg
Research Discipline: Cytoskeleton Markers
Gene ID (Entrez): 2312
Target Species: Human
Form: Purified
Antigen:
Filaggrin
Classification:
Monoclonal
Concentration:
1 mg/mL
Dilution:
Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Gene Alias:
ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery
Content And Storage:
Store at -20 to -80C. Avoid freeze-thaw cycles.
Isotype:
IgG1
Applications:
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Clone:
FLG/1561
Conjugate:
Unconjugated
Formulation:
PBS with No Preservative
Gene Symbols:
FLG
Immunogen:
Recombinant human Filaggrin protein fragment (aa 198-288) (exact sequence is proprietary)
Quantity:
200 μg
Research Discipline:
Cytoskeleton Markers
Gene ID (Entrez):
2312
Target Species:
Human
Form:
Purified
Antigen: SOS1
Classification: Polyclonal
Concentration: __
Dilution: Western Blot
Gene Alias: GF1GGF1, GINGF, guanine nucleotide exchange factor, HGFhereditary, 1, NS4, son of sevenless homolog 1, son of sevenless homolog 1 (Drosophila), SOS-1
Host Species: Rabbit
Purification Method: Immunogen affinity purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Store at 4°C in the dark.
Isotype: IgG
Applications: Western Blot
Clone: __
Conjugate: DyLight 680
Formulation: 50mM Sodium Borate
Gene Symbols: __
Immunogen: The immunogen recognized by this antibody maps to a region between residue 1025 and 1075 of human son of sevenless ortholog 1 using the numbering given in entry NP_005624.2 (GeneID 6654).
Quantity: 0.1 mL
Research Discipline: Breast Cancer, Cancer
Gene ID (Entrez): 6654
Target Species: Human
Form: Purified
Antigen:
SOS1
Classification:
Polyclonal
Concentration:
__
Dilution:
Western Blot
Gene Alias:
GF1GGF1, GINGF, guanine nucleotide exchange factor, HGFhereditary, 1, NS4, son of sevenless homolog 1, son of sevenless homolog 1 (Drosophila), SOS-1
Host Species:
Rabbit
Purification Method:
Immunogen affinity purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Store at 4°C in the dark.
Isotype:
IgG
Applications:
Western Blot
Clone:
__
Conjugate:
DyLight 680
Formulation:
50mM Sodium Borate
Gene Symbols:
__
Immunogen:
The immunogen recognized by this antibody maps to a region between residue 1025 and 1075 of human son of sevenless ortholog 1 using the numbering given in entry NP_005624.2 (GeneID 6654).
Quantity:
0.1 mL
Research Discipline:
Breast Cancer, Cancer
Gene ID (Entrez):
6654
Target Species:
Human
Form:
Purified