Tenascin C Antibody (DB7), Novus Biologicals™
Manufacturer: Novus Biologicals
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP142317-Each-of-1 | In Stock | ₹ 37,090.26 |
NBP142317 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,090.26
GST (18%): ₹ 6,676.247
Total Price: ₹ 43,766.507
Antigen
Tenascin C
Classification
Monoclonal
Concentration
0.1 mg/mL
Dilution
Western Blot 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500
Gene Symbols
TNC
Immunogen
The antibody reacts with the fibrinogen-like knob-domain of tenascin protein.
Quantity
0.05 mg
Research Discipline
Cancer, Neuroscience
Gene ID (Entrez)
3371
Target Species
Human, Rat
Form
Purified
Applications
Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Clone
DB7
Conjugate
Unconjugated
Gene Alias
150-225, Cytotactin, Glioma-associated-extracellular matrix antigen, GMEM, GP 150-225, Hexabrachion, hexabrachion (tenascin C, cytotactin), hexabrachion (tenascin), HXBcytotactin, JI, MGC167029, Myotendinous antigen, neuronectin, tenascin, tenascin C, Tenascin-C, tenascin-C isoform 14/AD1/16, TN-C, TNGP
Host Species
Mouse
Purification Method
Protein A or G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
The antibody recognizes the Mr 250000 and 180000 human tenascin polypeptides in immunoprecipitation and in immunoblots the Mr 250000 polypeptide. The antibody reacts with the fibrinogen-like knob-domain of tenascin protein. The antibody reacts especially with human paraffin sections. Tenascins were first characterized in the early 1980's. Since then hundreds of publications on tenascin in normal tissues, pathologically reactive tissues and carcinomas have been published. However, only recently more elective studies have been done. In these studies retrospective material from pathology files has been studied as well as larger fresh material collected during several years from patients. These studies have now attempted to reveal more specific points in carcinogenesis and pathological tissue reactions. It has been demonstrated that tenascin immunoreactivity in breast carcinoma cells could be indicative of metastasis and survival. Recent studies using retrospective material showed that the expression of tenascin in invasion border of early breast cancer significantly correlates with higher risk of distant metastasis. These studies have been continued now and the preliminary results clearly suggest that expression of tenascin in invasion border of early breast cancer is significantly associated with proliferative activity and higher risk of local recurrence. This result implicates a wide application for tenascin antibodies in the breast pathology. The point is that tenascin expression may suggest situations in which even small breast carcinomas may need more intensive complementary therapy (chemotherapy etc.). Recent studies have also shown that tenascin is significantly increased in airway basement membrane of asthmatics and rapidly decreases by inhaled steroid. This result suggests that tenascin expression may be used to monitor the disease status and outcome of treatment in different types of asthma. The monoclonal antibody to tenascin (clone DB7) is suitable for immunohistochemistry with formalin-fixed and paraffin-embedded sections. The other monoclonal antibody (clone EB2) is highly sensitive in Western blotting. Monoclonal antibody (Mab) to tenascin is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Tenascin polypeptides isolated from spent culture supernatant of human fibroblasts isolated by affinity chromatography were used as immunogen.
Content And Storage
Store at 4C. Do not freeze.
Isotype
IgG2a
Description
- Tenascin C Monoclonal specifically detects Tenascin C in Human, Rat samples
- It is validated for Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.
Compare Similar Items
Show Difference
Antigen: Tenascin C
Classification: Monoclonal
Concentration: 0.1 mg/mL
Dilution: Western Blot 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500
Gene Symbols: TNC
Immunogen: The antibody reacts with the fibrinogen-like knob-domain of tenascin protein.
Quantity: 0.05 mg
Research Discipline: Cancer, Neuroscience
Gene ID (Entrez): 3371
Target Species: Human, Rat
Form: Purified
Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Clone: DB7
Conjugate: Unconjugated
Gene Alias: 150-225, Cytotactin, Glioma-associated-extracellular matrix antigen, GMEM, GP 150-225, Hexabrachion, hexabrachion (tenascin C, cytotactin), hexabrachion (tenascin), HXBcytotactin, JI, MGC167029, Myotendinous antigen, neuronectin, tenascin, tenascin C, Tenascin-C, tenascin-C isoform 14/AD1/16, TN-C, TNGP
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: The antibody recognizes the Mr 250000 and 180000 human tenascin polypeptides in immunoprecipitation and in immunoblots the Mr 250000 polypeptide. The antibody reacts with the fibrinogen-like knob-domain of tenascin protein. The antibody reacts especially with human paraffin sections. Tenascins were first characterized in the early 1980's. Since then hundreds of publications on tenascin in normal tissues, pathologically reactive tissues and carcinomas have been published. However, only recently more elective studies have been done. In these studies retrospective material from pathology files has been studied as well as larger fresh material collected during several years from patients. These studies have now attempted to reveal more specific points in carcinogenesis and pathological tissue reactions. It has been demonstrated that tenascin immunoreactivity in breast carcinoma cells could be indicative of metastasis and survival. Recent studies using retrospective material showed that the expression of tenascin in invasion border of early breast cancer significantly correlates with higher risk of distant metastasis. These studies have been continued now and the preliminary results clearly suggest that expression of tenascin in invasion border of early breast cancer is significantly associated with proliferative activity and higher risk of local recurrence. This result implicates a wide application for tenascin antibodies in the breast pathology. The point is that tenascin expression may suggest situations in which even small breast carcinomas may need more intensive complementary therapy (chemotherapy etc.). Recent studies have also shown that tenascin is significantly increased in airway basement membrane of asthmatics and rapidly decreases by inhaled steroid. This result suggests that tenascin expression may be used to monitor the disease status and outcome of treatment in different types of asthma. The monoclonal antibody to tenascin (clone DB7) is suitable for immunohistochemistry with formalin-fixed and paraffin-embedded sections. The other monoclonal antibody (clone EB2) is highly sensitive in Western blotting. Monoclonal antibody (Mab) to tenascin is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Tenascin polypeptides isolated from spent culture supernatant of human fibroblasts isolated by affinity chromatography were used as immunogen.
Content And Storage: Store at 4C. Do not freeze.
Isotype: IgG2a
Antigen: Alpha Fodrin
Classification: Monoclonal
Concentration: 0.1 mg/mL
Dilution: Western Blot 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Gene Symbols: SPTAN1
Immunogen: The antibody reacts with the alpha-Fodrin antigen.
Quantity: 0.05 mg
Research Discipline: __
Gene ID (Entrez): 6709
Target Species: Human, Rat
Form: Purified
Applications: Western Blot, Immunohistochemistry, Immunohistochemistry (Frozen)
Clone: AA6
Conjugate: Unconjugated
Gene Alias: Alpha-II spectrin, EIEE5, FLJ17738, FLJ44613, Fodrin alpha chain, NEAS, spectrin alpha chain, brain, spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spectrin, non-erythroid alpha chain, SPTA2
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: The antibody is specific to the 240 kD a-fodrin molecule of all mammalian nonerythroid cells and chicken a-spectrin. The antibody cross reacts with human, rat, chicken, rabbit and guinea pig. Monoclonal antibody to a-fodrin is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Chicken red blood cell membranes purified by hypotonic lysis and mechanical enucleation were used as immunogen.
Content And Storage: Store at 4C. Do not freeze.
Isotype: IgG1
Antigen: Mouse IgM
Classification: Monoclonal
Concentration: __
Dilution: ELISA, Immunohistochemistry, Immunohistochemistry-Frozen
Gene Symbols: IGHM
Immunogen: The antibody reacts with the Mouse IgM antigen.
Quantity: 0.2 mL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Mouse
Form: Purified
Applications: ELISA, Immunohistochemistry, Immunohistochemistry (Frozen)
Clone: LO-MM-9
Conjugate: Alexa Fluor 488
Gene Alias: Constant region of heavy chain of IgM, DKFZp686I15196, DKFZp686I15212, FLJ00385, Hepatitis B virus receptor binding protein, Ig mu chain C region, IGHM, Immunoglobin heavy constant mu, Immunoglobulin heavy constant gamma 3, Immunoglobulin heavy mu chain, immunoglobulin mu, Immunoglobulin mu chain, Imunoglobulin heavy chain, MGC104996, MGC52291, mu, -region CH4 membrane bound domain, VH
Host Species: Rat
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Mouse mu heavy chain of immunoglobulin (determined by immunodot). Avidity on IgM: 7 * 10^8 M-1. No cross reactivity with other species.
Content And Storage: Store at 4C in the dark.
Isotype: IgG2a κ