NBP233138
Cyclin D1 Antibody (DCS-6) - Azide and BSA Free, Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP233138-Each-of-1 | In Stock | ₹ 55,271.76 |
NBP233138 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 55,271.76
GST (18%): ₹ 9,948.917
Total Price: ₹ 65,220.677
Antigen
Cyclin D1
Classification
Monoclonal
Concentration
1.0 mg/mL
Dilution
Western Blot, Flow Cytometry, ELISA 1-5ug/ml for coating, Immunohistochemistry-Paraffin, CyTOF-ready
Gene Symbols
CCND1
Immunogen
Human full length recombinant cyclin D1 protein (Uniprot: P24385)
Quantity
0.1 mg
Research Discipline
Cancer, Cell Cycle and Replication, Core ESC Like Genes, mTOR Pathway, Stem Cell Markers, Wnt Signaling Pathway
Gene ID (Entrez)
595
Target Species
Human, Mouse, Rat, Primate
Form
Purified
Applications
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry (Paraffin), CyTOF
Clone
DCS-6
Conjugate
Unconjugated
Gene Alias
B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, BCL1D11S287E, cyclin D1, cyclin D1 (PRAD1: parathyroid adenomatosis 1), G1/S-specific cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, PRAD1B-cell CLL/lymphoma 1, U21B31
Host Species
Mouse
Purification Method
Protein A or G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Content And Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype
IgG2a κ
Related Products
Description
- Cyclin D1 Monoclonal specifically detects Cyclin D1 in Human, Mouse, Rat, Monkey samples
- It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.
Compare Similar Items
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Antigen: Cyclin D1
Classification: Monoclonal
Concentration: 1.0 mg/mL
Dilution: Western Blot, Flow Cytometry, ELISA 1-5ug/ml for coating, Immunohistochemistry-Paraffin, CyTOF-ready
Gene Symbols: CCND1
Immunogen: Human full length recombinant cyclin D1 protein (Uniprot: P24385)
Quantity: 0.1 mg
Research Discipline: Cancer, Cell Cycle and Replication, Core ESC Like Genes, mTOR Pathway, Stem Cell Markers, Wnt Signaling Pathway
Gene ID (Entrez): 595
Target Species: Human, Mouse, Rat, Primate
Form: Purified
Applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry (Paraffin), CyTOF
Clone: DCS-6
Conjugate: Unconjugated
Gene Alias: B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, BCL1D11S287E, cyclin D1, cyclin D1 (PRAD1: parathyroid adenomatosis 1), G1/S-specific cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, PRAD1B-cell CLL/lymphoma 1, U21B31
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype: IgG2a κ
Antigen:
Cyclin D1
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Dilution:
Western Blot, Flow Cytometry, ELISA 1-5ug/ml for coating, Immunohistochemistry-Paraffin, CyTOF-ready
Gene Symbols:
CCND1
Immunogen:
Human full length recombinant cyclin D1 protein (Uniprot: P24385)
Quantity:
0.1 mg
Research Discipline:
Cancer, Cell Cycle and Replication, Core ESC Like Genes, mTOR Pathway, Stem Cell Markers, Wnt Signaling Pathway
Gene ID (Entrez):
595
Target Species:
Human, Mouse, Rat, Primate
Form:
Purified
Applications:
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry (Paraffin), CyTOF
Clone:
DCS-6
Conjugate:
Unconjugated
Gene Alias:
B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, BCL1D11S287E, cyclin D1, cyclin D1 (PRAD1: parathyroid adenomatosis 1), G1/S-specific cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, PRAD1B-cell CLL/lymphoma 1, U21B31
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgG2a κ
Antigen: CD43/Sialophorin
Classification: Monoclonal
Concentration: 1.0 mg/mL
Dilution: ELISA 1-5ug/ml for coating
Gene Symbols: SPN
Immunogen: Myeloblastic KG1 cells were used as the immunogen for this antibody.
Quantity: 0.1 mg
Research Discipline: Immunology
Gene ID (Entrez): 6693
Target Species: Human
Form: Purified
Applications: ELISA
Clone: DF-T1
Conjugate: Unconjugated
Gene Alias: CD43 antigen, CD43), Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, sialophorin (gpL115, leukosialin, CD43)
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: It recognizes a cell surface glycoprotein of 95/115/135kDa (depending upon the extent of glycosylation), identified as CD43 [Workshop IV]. Epitope of monoclonal antibody Bra7G is clearly different from that of monoclonal antibody DF-T1, called b as opposed to a for DF-T1. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype: IgG1 κ
Antigen:
CD43/Sialophorin
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Dilution:
ELISA 1-5ug/ml for coating
Gene Symbols:
SPN
Immunogen:
Myeloblastic KG1 cells were used as the immunogen for this antibody.
Quantity:
0.1 mg
Research Discipline:
Immunology
Gene ID (Entrez):
6693
Target Species:
Human
Form:
Purified
Applications:
ELISA
Clone:
DF-T1
Conjugate:
Unconjugated
Gene Alias:
CD43 antigen, CD43), Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, sialophorin (gpL115, leukosialin, CD43)
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
It recognizes a cell surface glycoprotein of 95/115/135kDa (depending upon the extent of glycosylation), identified as CD43 [Workshop IV]. Epitope of monoclonal antibody Bra7G is clearly different from that of monoclonal antibody DF-T1, called b as opposed to a for DF-T1. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgG1 κ
Antigen: Kappa Light Chain
Classification: Monoclonal
Concentration: __
Dilution: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Gene Symbols: IGKC
Immunogen: B lymphoma cells
Quantity: 0.1 mL
Research Discipline: __
Gene ID (Entrez): 3514
Target Species: Human
Form: Purified
Applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clone: L1C1
Conjugate: DyLight 680
Gene Alias: HCAK1, IGKCD, immunoglobulin kappa constant, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Content And Storage: Store at 4C in the dark.
Isotype: IgG1 κ
Antigen:
Kappa Light Chain
Classification:
Monoclonal
Concentration:
__
Dilution:
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Gene Symbols:
IGKC
Immunogen:
B lymphoma cells
Quantity:
0.1 mL
Research Discipline:
__
Gene ID (Entrez):
3514
Target Species:
Human
Form:
Purified
Applications:
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clone:
L1C1
Conjugate:
DyLight 680
Gene Alias:
HCAK1, IGKCD, immunoglobulin kappa constant, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Content And Storage:
Store at 4C in the dark.
Isotype:
IgG1 κ
Antigen: Kappa Light Chain
Classification: Monoclonal
Concentration: __
Dilution: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Gene Symbols: IGKC
Immunogen: B lymphoma cells
Quantity: 0.1 mL
Research Discipline: __
Gene ID (Entrez): 3514
Target Species: Human
Form: Purified
Applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clone: L1C1
Conjugate: DyLight 488
Gene Alias: HCAK1, IGKCD, immunoglobulin kappa constant, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Content And Storage: Store at 4C in the dark.
Isotype: IgG1 κ
Antigen:
Kappa Light Chain
Classification:
Monoclonal
Concentration:
__
Dilution:
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Gene Symbols:
IGKC
Immunogen:
B lymphoma cells
Quantity:
0.1 mL
Research Discipline:
__
Gene ID (Entrez):
3514
Target Species:
Human
Form:
Purified
Applications:
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clone:
L1C1
Conjugate:
DyLight 488
Gene Alias:
HCAK1, IGKCD, immunoglobulin kappa constant, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Content And Storage:
Store at 4C in the dark.
Isotype:
IgG1 κ