Manufacturer: Fischer Scientific
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PTH
Monoclonal
0.2mg/mL
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
P01270
PTH
Recombinant fragment (84 amino acid residues from C-terminus) of human PTH protein
Protein A or G purified
RUO
Primary
Epitope of this MAb maps in the C-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
Store at 4C.
IgG2b κ
Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence
PTH/1173
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Parathormone, Parathyrin, parathyroid hormone, parathyroid hormone 1, PTH1
Mouse
9 kDa
0.2 mg
Apoptosis, Cancer
5741
Human
Purified