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NBP247888B

MUC1 Antibody (139H2) - Azide and BSA Free, Novus Biologicals™

Manufacturer: Fischer Scientific

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Antigen

MUC-1

Classification

Monoclonal

Concentration

1.0 mg/mL

Dilution

Flow Cytometry : 0.25 - 0.5 ug/million cells in 0.1ml, ELISA, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Immunofluorescence : 1 - 2 ug/ml, CyTOF-ready

Gene Alias

Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, CD227, CD227 antigen, DF3 antigen, EMA, episialin, H23 antigen, H23AG, KL-6, MAM6, MUC-1, MUC1/ZD, mucin 1, cell surface associated, mucin 1, transmembrane, mucin-1, Peanut-reactive urinary mucin, PEMMUC-1/SEC, PEMT, Polymorphic epithelial mucin, PUMMUC-1/X, tumor associated epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin

Host Species

Mouse

Purification Method

Protein A or G purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.

Content And Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Isotype

IgG1 κ

Applications

Flow Cytometry, ELISA, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF

Clone

139H2

Conjugate

Unconjugated

Formulation

PBS with No Preservative

Gene Symbols

MUC1

Immunogen

Human milk-fat globule membranes (HMFGM)

Quantity

0.2 mg

Research Discipline

Cancer, Cellular Markers, Extracellular Matrix

Gene ID (Entrez)

4582

Target Species

Human, Mouse

Form

Purified

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Description

  • MUC1 Monoclonal specifically detects MUC1 in Human, Mouse samples
  • It is validated for Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence, CyTOF-ready.

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Fischer Scientific

NBP247888B

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Antigen:
MUC-1
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Dilution:
Flow Cytometry : 0.25 - 0.5 ug/million cells in 0.1ml, ELISA, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Immunofluorescence : 1 - 2 ug/ml, CyTOF-ready
Gene Alias:
Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, CD227, CD227 antigen, DF3 antigen, EMA, episialin, H23 antigen, H23AG, KL-6, MAM6, MUC-1, MUC1/ZD, mucin 1, cell surface associated, mucin 1, transmembrane, mucin-1, Peanut-reactive urinary mucin, PEMMUC-1/SEC, PEMT, Polymorphic epithelial mucin, PUMMUC-1/X, tumor associated epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
Host Species:
Mouse
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgG1 κ
Applications:
Flow Cytometry, ELISA, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF
Clone:
139H2
Conjugate:
Unconjugated
Formulation:
PBS with No Preservative
Gene Symbols:
MUC1
Immunogen:
Human milk-fat globule membranes (HMFGM)
Quantity:
0.2 mg
Research Discipline:
Cancer, Cellular Markers, Extracellular Matrix
Gene ID (Entrez):
4582
Target Species:
Human, Mouse
Form:
Purified

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Novus Biologicals™

NBP24788PEP

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Antigen:
__
Classification:
__
Concentration:
__
Dilution:
__
Gene Alias:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
RUO
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
Store at -20°C. Avoid freeze-thaw cycles.
Isotype:
__
Applications:
__
Clone:
__
Conjugate:
__
Formulation:
PBS and 1M Urea, pH 7.4.
Gene Symbols:
__
Immunogen:
__
Quantity:
100 μl
Research Discipline:
__
Gene ID (Entrez):
10998
Target Species:
__
Form:
__

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NBP247890A

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Antigen:
ST6 Gal Sialyltransferase 1/ST6GAL1/CD75
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Dilution:
Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Immunofluorescence : 0.5 - 1.0 ug/ml, CyTOF-ready
Gene Alias:
B-cell antigen CD75, beta-galactoside alpha-2,6-sialyltransferase 1, CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferase, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1, EC 2.4.99.1, MGC48859, Sialyltransferase 1, sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase), sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase), SIAT1Alpha 2,6-ST 1, ST6 beta-galactosamide alpha-2,6-sialyltranferase 1, ST6Gal I, ST6GalI, ST6N
Host Species:
Mouse
Purification Method:
PEG purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Recognizes a neuraminidase-sensitive sialoprotein (CDw75), present on cell membrane and cytoplasm of germinal center B-cells and derived lymphomas. This MAb reacts with RBC precursors of bone marrow, ductal and ciliated epithelial cells of kidney, breast, prostate, pancreas, lung, and with glioblastomas, astrocytomas, and Reed Sternberg cells in lymphocyte predominant Hodgkin s disease. It is shown to be a helpful antibody for ascribing a B-cell phenotype in known lymphoid tissues.
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgM κ
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF
Clone:
LN-1
Conjugate:
Unconjugated
Formulation:
PBS with No Preservative
Gene Symbols:
ST6GAL1
Immunogen:
Nuclei from pokeweed mitogen-stimulated peripheral blood lymphocytes.
Quantity:
0.1 mg
Research Discipline:
Golgi Apparatus Markers
Gene ID (Entrez):
6480
Target Species:
Human
Form:
Purified

Img

Fischer Scientific

NBP247890B

--

Antigen:
ST6 Gal Sialyltransferase 1/ST6GAL1/CD75
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Dilution:
Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Immunofluorescence : 0.5 - 1.0 ug/ml, CyTOF-ready
Gene Alias:
B-cell antigen CD75, beta-galactoside alpha-2,6-sialyltransferase 1, CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferase, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1, EC 2.4.99.1, MGC48859, Sialyltransferase 1, sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase), sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase), SIAT1Alpha 2,6-ST 1, ST6 beta-galactosamide alpha-2,6-sialyltranferase 1, ST6Gal I, ST6GalI, ST6N
Host Species:
Mouse
Purification Method:
PEG purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Recognizes a neuraminidase-sensitive sialoprotein (CDw75), present on cell membrane and cytoplasm of germinal center B-cells and derived lymphomas. This MAb reacts with RBC precursors of bone marrow, ductal and ciliated epithelial cells of kidney, breast, prostate, pancreas, lung, and with glioblastomas, astrocytomas, and Reed Sternberg cells in lymphocyte predominant Hodgkin s disease. It is shown to be a helpful antibody for ascribing a B-cell phenotype in known lymphoid tissues.
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgM κ
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF
Clone:
LN-1
Conjugate:
Unconjugated
Formulation:
PBS with No Preservative
Gene Symbols:
ST6GAL1
Immunogen:
Nuclei from pokeweed mitogen-stimulated peripheral blood lymphocytes.
Quantity:
0.2 mg
Research Discipline:
Golgi Apparatus Markers
Gene ID (Entrez):
6480
Target Species:
Human
Form:
Purified