Fascin Antibody (FSCN1/418) - IHC-Prediluted, Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP248337-Each-of-1 | In Stock | ₹ 44,833.44 |
NBP248337 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,833.44
GST (18%): ₹ 8,070.019
Total Price: ₹ 52,903.459
Antigen
Fascin
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols
FSCN1
Immunogen
Full length recombinant human Fascin protein (Uniprot: Q16658)
Purification Method
Protein A or G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkins disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Content And Storage
Store at 4C.
Isotype
IgG2b κ
Applications
Immunohistochemistry (Paraffin)
Clone
FSCN1/418
Dilution
Immunohistochemistry-Paraffin
Gene Alias
FAN1,55 kDa actin-bundling protein, fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), FLJ38511, HSN, p55actin bundling protein, singed (Drosophila)-like (sea urchin fascin homolog like), singed-like (fascin homolog, sea urchin), Singed-like protein, SNLfascin
Host Species
Mouse
Molecular Weight of Antigen
55 kDa
Quantity
7 mL
Research Discipline
Cytoskeleton Markers
Gene ID (Entrez)
6624
Target Species
Human, Rat
Form
Purified
Related Products
Description
- Fascin Monoclonal specifically detects Fascin in Human, Rat samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
Compare Similar Items
Show Difference
Antigen: Fascin
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: FSCN1
Immunogen: Full length recombinant human Fascin protein (Uniprot: Q16658)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkins disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Content And Storage: Store at 4C.
Isotype: IgG2b κ
Applications: Immunohistochemistry (Paraffin)
Clone: FSCN1/418
Dilution: Immunohistochemistry-Paraffin
Gene Alias: FAN1,55 kDa actin-bundling protein, fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), FLJ38511, HSN, p55actin bundling protein, singed (Drosophila)-like (sea urchin fascin homolog like), singed-like (fascin homolog, sea urchin), Singed-like protein, SNLfascin
Host Species: Mouse
Molecular Weight of Antigen: 55 kDa
Quantity: 7 mL
Research Discipline: Cytoskeleton Markers
Gene ID (Entrez): 6624
Target Species: Human, Rat
Form: Purified
Antigen: Gastric Mucin
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: MUC6
Immunogen: A synthetic peptide of the Gastric MUC6 tandem repeat sequence (Uniprot: Q6W4X9 )
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin)
Clone: CLH5
Dilution: Immunohistochemistry-Paraffin
Gene Alias: Gastric mucin-6, MUC-6, mucin 6, gastric, mucin 6, oligomeric mucus/gel-forming, mucin-6
Host Species: Mouse
Molecular Weight of Antigen: 252 kDa
Quantity: 7 mL
Research Discipline: __
Gene ID (Entrez): 4588
Target Species: Human
Form: Purified
Antigen: Gastric Mucin
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: MUC6
Immunogen: A synthetic peptide of the Gastric MUC6 tandem repeat sequence (Uniprot: Q6W4X9)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin)
Clone: SPM598
Dilution: Immunohistochemistry-Paraffin
Gene Alias: Gastric mucin-6, MUC-6, mucin 6, gastric, mucin 6, oligomeric mucus/gel-forming, mucin-6
Host Species: Mouse
Molecular Weight of Antigen: 252 kDa
Quantity: 7 mL
Research Discipline: __
Gene ID (Entrez): 4588
Target Species: Human
Form: Purified