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NP247708A70

SOX10 Antibody (SPM607), Alexa Fluor™ 750, Novus Biologicals™

Manufacturer: Novus Biologicals

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Pack Size SKU Availability Price
Each of 1 NP247708A70-Each-of-1 In Stock ₹ 55,271.76

NP247708A70 - Each of 1

₹ 55,271.76

In Stock

Quantity

1

Base Price: ₹ 55,271.76

GST (18%): ₹ 9,948.917

Total Price: ₹ 65,220.677

Antigen

SOX10

Classification

Monoclonal

Conjugate

Alexa Fluor 750

Formulation

50 mM sodium borate with 0.05% sodium azide

Gene Symbols

SOX10

Immunogen

Recombinant fragment (aa 115-269) of human SOX10 protein with hexa-histidine tag (Uniprot: P56693)

Primary or Secondary

Primary

Test Specificity

Recognizes a protein of ∼55kDa, identified as SOX10. This monoclonal antibody is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal ti

Content And Storage

Store at 4°C in the dark.

Applications

Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence

Clone

SPM607

Dilution

Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence

Gene Alias

MGC15649, PCWH, SRY (sex determining region Y)-box 10, SRY-related HMG-box gene 10, transcription factor SOX-10, WS4C, WS4mouse, human homolog of

Host Species

Mouse

Quantity

0.1 mL

Gene ID (Entrez)

6663

Target Species

Human

Isotype

IgG2b κ

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Description

  • SOX10 Monoclonal specifically detects SOX10 in Human samples
  • It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.

Compare Similar Items

Show Difference

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Novus Biologicals

NP247708A70

--

Antigen:
SOX10
Classification:
Monoclonal
Conjugate:
Alexa Fluor 750
Formulation:
50 mM sodium borate with 0.05% sodium azide
Gene Symbols:
SOX10
Immunogen:
Recombinant fragment (aa 115-269) of human SOX10 protein with hexa-histidine tag (Uniprot: P56693)
Primary or Secondary:
Primary
Test Specificity:
Recognizes a protein of ∼55kDa, identified as SOX10. This monoclonal antibody is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal ti
Content And Storage:
Store at 4°C in the dark.
Applications:
Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Clone:
SPM607
Dilution:
Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Gene Alias:
MGC15649, PCWH, SRY (sex determining region Y)-box 10, SRY-related HMG-box gene 10, transcription factor SOX-10, WS4C, WS4mouse, human homolog of
Host Species:
Mouse
Quantity:
0.1 mL
Gene ID (Entrez):
6663
Target Species:
Human
Isotype:
IgG2b κ

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Antigen:
Histone H2B
Classification:
Monoclonal
Conjugate:
Alexa Fluor 350
Formulation:
50 mM sodium borate with 0.05% sodium azide
Gene Symbols:
HIST2H2BF
Immunogen:
Ub-polypeptide antigen based on amino acids 115 - 130 of yeast Histone H2B
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Store at 4°C in the dark.
Applications:
Western Blot, ELISA, Immunocytochemistry, Immunofluorescence
Clone:
1B3F12/A9
Dilution:
Western Blot, ELISA, Immunocytochemistry/Immunofluorescence
Gene Alias:
FLJ35099, FLJ56780, FLJ56787, histone 2, H2bf, histone cluster 2, H2bf, histone H2B type 2-F, MGC131639
Host Species:
Mouse
Quantity:
0.1 mL
Gene ID (Entrez):
440689
Target Species:
Human, Yeast
Isotype:
IgG1

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Novus Biologicals

NP24770A32

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Antigen:
Histone H2B
Classification:
Monoclonal
Conjugate:
Alexa Fluor 532
Formulation:
50 mM sodium borate with 0.05% sodium azide
Gene Symbols:
HIST2H2BF
Immunogen:
Ub-polypeptide antigen based on amino acids 115 - 130 of yeast Histone H2B
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Store at 4°C in the dark.
Applications:
Western Blot, ELISA, Immunocytochemistry, Immunofluorescence
Clone:
1B3F12/A9
Dilution:
Western Blot, ELISA, Immunocytochemistry/Immunofluorescence
Gene Alias:
FLJ35099, FLJ56780, FLJ56787, histone 2, H2bf, histone cluster 2, H2bf, histone H2B type 2-F, MGC131639
Host Species:
Mouse
Quantity:
0.1 mL
Gene ID (Entrez):
440689
Target Species:
Human, Yeast
Isotype:
IgG1

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Novus Biologicals

NP24770A350

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Antigen:
beta 2-Microglobulin
Classification:
Monoclonal
Conjugate:
Alexa Fluor 350
Formulation:
50 mM sodium borate with 0.05% sodium azide
Gene Symbols:
B2M
Immunogen:
Human PBL s from a T-cell acute lymphoblastic leukemia (T-ALL) patient.
Primary or Secondary:
Primary
Test Specificity:
Recognizes a protein of 12kDa, identified as beta-microglobulin. Beta--microglobulin non-covalently associates with the 44kDa chain to form the HLA Class I antigen complex. Human beta-2 microglobulin associated with HLA Class I antigens is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes. This monoclonal antibody is specific to human beta-2 microglobulin and does not react with non-human primate cells. This antibody reacts with all cell types excluding erythrocytes. Detection of beta-2 microglobulin in body fluids has been used as a tumor marker and for monitoring patients with HIV infection.
Content And Storage:
Store at 4°C in the dark.
Applications:
Flow Cytometry, Immunofluorescence
Clone:
246-E9.E7 (same as HLA.ABC.m2)
Dilution:
Flow Cytometry, Immunofluorescence
Gene Alias:
beta chain of MHC class I molecules, beta-2-microglobin, beta-2-microglobulin
Host Species:
Mouse
Quantity:
0.1 mL
Gene ID (Entrez):
567
Target Species:
Human, Primate
Isotype:
IgG2a κ