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NP2479A94

Fc gamma RIII (CD16) Antibody (ICO-116), Alexa Fluor™ 594, Novus Biologicals™

Manufacturer: Novus Biologicals

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Pack Size SKU Availability Price
Each of 1 NP2479A94-Each-of-1 In Stock ₹ 55,271.76

NP2479A94 - Each of 1

₹ 55,271.76

In Stock

Quantity

1

Base Price: ₹ 55,271.76

GST (18%): ₹ 9,948.917

Total Price: ₹ 65,220.677

Antigen

Fc gamma RIIIA/CD16a

Classification

Monoclonal

Conjugate

Alexa Fluor 594

Formulation

50 mM sodium borate with 0.05% sodium azide

Gene Symbols

FCGR3A

Immunogen

Human Fc gamma RIII (CD16) protein (Uniprot: P08637)

Research Discipline

Cell Biology, Cellular Markers, Cytokine Research, Growth and Development, Hematopoietic Stem Cell Markers, Immunology, Innate Immunity, Neuronal Cell Markers, Neuroscience, Stem Cell Markers, Stem Cells

Gene ID (Entrez)

2214

Target Species

Human

Isotype

IgG1 κ

Applications

Flow Cytometry, Immunofluorescence

Clone

ICO-116

Dilution

Flow Cytometry, Immunofluorescence

Gene Alias

CD16a, CD16a antigen, CD16FCRIIIA, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), Fc fragment of IgG, low affinity IIIa, receptor for (CD16), Fc gamma receptor III-A, FCG3, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD16), Fc-gamma RIII, Fc-gamma RIIIa, Fc-gamma RIII-alpha, FCGR3, FCGRIII, FCR-10, FcRIII, FcRIIIa, IGFR3FcgammaRIIIA, immunoglobulin G Fc receptor III, low affinity III, receptor for (CD16), low affinity immunoglobulin gamma Fc region receptor III-A, neutrophil-specific antigen NA

Host Species

Mouse

Quantity

0.1 mL

Primary or Secondary

Primary

Test Specificity

It recognizes CD16 (Fcgamma RIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16, CD16A (Fcgamma RIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fcgamma RIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

Content And Storage

Store at 4°C in the dark.

Description

  • Fc gamma RIII (CD16) Monoclonal specifically detects Fc gamma RIII (CD16) in Human samples
  • It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunofluorescence.

Compare Similar Items

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Novus Biologicals

NP2479A94

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Antigen:
Fc gamma RIIIA/CD16a
Classification:
Monoclonal
Conjugate:
Alexa Fluor 594
Formulation:
50 mM sodium borate with 0.05% sodium azide
Gene Symbols:
FCGR3A
Immunogen:
Human Fc gamma RIII (CD16) protein (Uniprot: P08637)
Research Discipline:
Cell Biology, Cellular Markers, Cytokine Research, Growth and Development, Hematopoietic Stem Cell Markers, Immunology, Innate Immunity, Neuronal Cell Markers, Neuroscience, Stem Cell Markers, Stem Cells
Gene ID (Entrez):
2214
Target Species:
Human
Isotype:
IgG1 κ
Applications:
Flow Cytometry, Immunofluorescence
Clone:
ICO-116
Dilution:
Flow Cytometry, Immunofluorescence
Gene Alias:
CD16a, CD16a antigen, CD16FCRIIIA, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), Fc fragment of IgG, low affinity IIIa, receptor for (CD16), Fc gamma receptor III-A, FCG3, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD16), Fc-gamma RIII, Fc-gamma RIIIa, Fc-gamma RIII-alpha, FCGR3, FCGRIII, FCR-10, FcRIII, FcRIIIa, IGFR3FcgammaRIIIA, immunoglobulin G Fc receptor III, low affinity III, receptor for (CD16), low affinity immunoglobulin gamma Fc region receptor III-A, neutrophil-specific antigen NA
Host Species:
Mouse
Quantity:
0.1 mL
Primary or Secondary:
Primary
Test Specificity:
It recognizes CD16 (Fcgamma RIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16, CD16A (Fcgamma RIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fcgamma RIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
Content And Storage:
Store at 4°C in the dark.

Img

Novus Biologicals

NP247A32

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Antigen:
CD30/TNFRSF8
Classification:
Monoclonal
Conjugate:
Alexa Fluor 532
Formulation:
50 mM sodium borate with 0.05% sodium azide
Gene Symbols:
TNFRSF8
Immunogen:
Recombinant human full-length CD30/TNFRSF8 protein (Uniprot: P28908)
Research Discipline:
__
Gene ID (Entrez):
943
Target Species:
Human
Isotype:
IgG
Applications:
Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Clone:
Ki-1/1505R
Dilution:
Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
Gene Alias:
CD30, CD30 antigen, CD30KI-1, CD30L receptor, cytokine receptor CD30, D1S166EKi-1, Ki-1 antigen, Lymphocyte activation antigen CD30, tumor necrosis factor receptor superfamily member 8, tumor necrosis factor receptor superfamily, member 8
Host Species:
Rabbit
Quantity:
0.1 mL
Primary or Secondary:
Primary
Test Specificity:
Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkins disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This monoclonal antibody distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
Content And Storage:
Store at 4°C in the dark.

Img

Novus Biologicals

NP247A94

--

Antigen:
CD30/TNFRSF8
Classification:
Monoclonal
Conjugate:
Alexa Fluor 594
Formulation:
50 mM sodium borate with 0.05% sodium azide
Gene Symbols:
TNFRSF8
Immunogen:
Recombinant human full-length CD30/TNFRSF8 protein (Uniprot: P28908)
Research Discipline:
__
Gene ID (Entrez):
943
Target Species:
Human
Isotype:
IgG
Applications:
Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Clone:
Ki-1/1505R
Dilution:
Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
Gene Alias:
CD30, CD30 antigen, CD30KI-1, CD30L receptor, cytokine receptor CD30, D1S166EKi-1, Ki-1 antigen, Lymphocyte activation antigen CD30, tumor necrosis factor receptor superfamily member 8, tumor necrosis factor receptor superfamily, member 8
Host Species:
Rabbit
Quantity:
0.1 mL
Primary or Secondary:
Primary
Test Specificity:
Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkins disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This monoclonal antibody distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
Content And Storage:
Store at 4°C in the dark.

Img

Novus Biologicals

NP24800A350

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Antigen:
Arginase 1/ARG1/liver Arginase
Classification:
Monoclonal
Conjugate:
Alexa Fluor 350
Formulation:
50 mM sodium borate with 0.05% sodium azide
Gene Symbols:
ARG1
Immunogen:
Recombinant human Arginase 1/ARG1/liver Arginase protein fragment (around aa11-97) (exact sequence is proprietary) (Uniprot: P05089 )
Research Discipline:
Cancer, Cellular Markers, Chromatin Research, Lipid and Metabolism, Myeloid derived Suppressor Cell
Gene ID (Entrez):
383.0
Target Species:
Human
Isotype:
IgG3 κ
Applications:
Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Clone:
ARG1/1125 + ARG1/1126
Dilution:
Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Gene Alias:
arginase 1, arginase, liver, arginase-1, EC 3.5.3.1, Liver-type arginase, Type I arginase
Host Species:
Mouse
Quantity:
0.1 mL
Primary or Secondary:
Primary
Test Specificity:
Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes, which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.
Content And Storage:
Store at 4°C in the dark.