PA14514

ARC Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PA14514-Each-of-1 In Stock ₹ 39,015.36

PA14514 - Each of 1

₹ 39,015.36

In Stock

Quantity

1

Base Price: ₹ 39,015.36

GST (18%): ₹ 7,022.765

Total Price: ₹ 46,038.125

Antigen

ARC

Classification

Polyclonal

Conjugate

Unconjugated

Gene

NOL3

Gene Alias

activity regulated cytoskeletal-associated protein; activity regulated cytoskeleton associated protein; activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein; activity-regulated gene 3.1 protein homolog; Apoptosis repressor with CARD; ARC; arc {ECO:0000312; ARC/ARG3.1; Arc3.1; Arg3.1; B430311C09Rik; C86064; FCM; hArc; KIAA0278; mArc; Muscle-enriched cytoplasmic protein; MYC; MYP; Nol3; NOP; Nop 30; Nop30; Nucleolar protein 3; nucleolar protein 3 (apoptosis repressor with CARD domain); nucleolar protein of 30 kDa; rg3.1; RGD:62037}

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

8996

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Western Blot

Concentration

1 mg/mL

Formulation

PBS with 0.02% sodium azide

Gene Accession No.

O60936

Gene Symbols

NOL3

Immunogen

Synthetic peptide: P(125) E L Q T L T R P G A L R A P R R(141)

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

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Description

  • PA1-4514 detects splice variants Nop30/ARC of the nucleolar protein Nop30 in human samples
  • PA1-4514 has been used successfully in Western blot procedures
  • By Western blot this antibody detects a ∽25 kDa protein representing recombinant Nop30
  • The PA1-4514 immunogen corresponds to amino acid residues 125-141 of the 25 kDa human Nop30/ARC protein
  • ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms
  • Isoform 1 is involved in RNA splicing
  • Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death
  • ARC inhibits extrinsic apoptotic pathways two different ways
  • The first is by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly
  • The second way is by interacting with CASP8 in a mitochondria localization-and phosphorylation-dependent manner, which in turn limits the amount of soluble CASP8 avaliable for DISC-mediated activation
  • ARC also inhibits intrinsic apoptotic pathways in response to a wide range of stresses through interactions with BAX
  • This results in BAX inactivation and prevents mitochondrial dysfunction and release of pro-apoptotic factors
  • Mutations affecting the gene can results in myoclonus, familiam cortical.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PA14514

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Antigen:
ARC

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
NOL3

Gene Alias:
activity regulated cytoskeletal-associated protein; activity regulated cytoskeleton associated protein; activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein; activity-regulated gene 3.1 protein homolog; Apoptosis repressor with CARD; ARC; arc {ECO:0000312; ARC/ARG3.1; Arc3.1; Arg3.1; B430311C09Rik; C86064; FCM; hArc; KIAA0278; mArc; Muscle-enriched cytoplasmic protein; MYC; MYP; Nol3; NOP; Nop 30; Nop30; Nucleolar protein 3; nucleolar protein 3 (apoptosis repressor with CARD domain); nucleolar protein of 30 kDa; rg3.1; RGD:62037}

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
8996

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.02% sodium azide

Gene Accession No.:
O60936

Gene Symbols:
NOL3

Immunogen:
Synthetic peptide: P(125) E L Q T L T R P G A L R A P R R(141)

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PA14515

--


Antigen:
PINK1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
PINK1

Gene Alias:
1190006F07Rik; AU042772; AW557854; BRPK; FLJ27236; mFLJ00387; PARK6; PINK 1; Pink1; PINK-1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
65018

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.02% sodium azide

Gene Accession No.:
Q9BXM7

Gene Symbols:
PINK1

Immunogen:
Synthetic peptide: Y(258) R K S K R G P K Q L A P H P N I(274)

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PA14558

--


Antigen:
OPRD1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
OPRD1

Gene Alias:
delta 1 opioid receptor; delta opioid receptor 1; delta-type opioid receptor; DOR; D-OR-1; DOR-1; K56; mDOR; MSL-2; Nbor; Opioid receptor; opioid receptor A; opioid receptor delta 1; opioid receptor, delta 1; OPRD; Oprd1; Ror-a

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
18386, 24613, 4985

Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.02% sodium azide

Gene Accession No.:
P32300, P33533, P41143

Gene Symbols:
OPRD1

Immunogen:
Synthetic peptide corresponding to residues L(3) V P S A R A E L Q S S P L V(17) of mouse and rat DOR-1.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PA14560

--


Antigen:
OPRD1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
OPRD1

Gene Alias:
delta 1 opioid receptor; delta opioid receptor 1; delta-type opioid receptor; DOR; D-OR-1; DOR-1; K56; mDOR; MSL-2; Nbor; Opioid receptor; opioid receptor A; opioid receptor delta 1; opioid receptor, delta 1; OPRD; Oprd1; Ror-a

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
18386, 24613, 4985

Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.02% sodium azide

Gene Accession No.:
P32300, P33533, P41143

Gene Symbols:
OPRD1

Immunogen:
Synthetic peptide corresponding to residues T(361) P S D G P G G G A A A(372) of human DOR-1.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG