PA551118

c-Mpl Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 PA551118-Each-of-1 In Stock ₹ 47,528.58

PA551118 - Each of 1

₹ 47,528.58

In Stock

Quantity

1

Base Price: ₹ 47,528.58

GST (18%): ₹ 8,555.144

Total Price: ₹ 56,083.724

Antigen

c-Mpl

Classification

Polyclonal

Conjugate

Unconjugated

Gene

MPL

Gene Alias

CD110; c-mpl; hlb219; MPL; MPL proto-oncogene, thrombopoietin receptor; MPLV; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; proto-oncogene c-Mpl; THCYT2; thrombopoietin receptor; TPOR; TPO-R

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

17480, 366455, 4352

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

ELISA, Western Blot

Concentration

1 mg/mL

Formulation

PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.

P40238, Q08351

Gene Symbols

MPL

Immunogen

Synthesized peptide derived from the Internal region of human CD110.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • c-Mpl / CD110 Polyclonal Antibody detects endogenous levels of c-Mpl / CD110 protein
  • In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages
  • In 1992 the human homologue, named, c-mpl, was cloned
  • Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily
  • Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation
  • The ligand for c-mpl, thrombopoietin, was cloned in 1994
  • Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation
  • The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs
  • TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation
  • Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Compare Similar Items

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Thermo Scientific

PA551118

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Antigen:
c-Mpl

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
MPL

Gene Alias:
CD110; c-mpl; hlb219; MPL; MPL proto-oncogene, thrombopoietin receptor; MPLV; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; proto-oncogene c-Mpl; THCYT2; thrombopoietin receptor; TPOR; TPO-R

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
17480, 366455, 4352

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
ELISA, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P40238, Q08351

Gene Symbols:
MPL

Immunogen:
Synthesized peptide derived from the Internal region of human CD110.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

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PA551120

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Antigen:
POLR3G

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
POLR3G

Gene Alias:
2310047G20Rik; AV275904; DNA-directed RNA polymerase III 32 kDa polypeptide; DNA-directed RNA polymerase III subunit G; DNA-directed RNA polymerase III subunit RPC7; Polr3g; polymerase (RNA) III (DNA directed) polypeptide G; polymerase (RNA) III (DNA directed) polypeptide G (32kD); polymerase (RNA) III subunit G; RNA polymerase III 32 kDa apha subunit; RNA polymerase III 32 kDa subunit; RNA polymerase III subunit C7; RNA polymerase III subunit G; RPC32; RPC32-alpha; RPC7

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
10622, 67486

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
ELISA, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
O15318, Q6NXY9

Gene Symbols:
POLR3G

Immunogen:
Synthesized peptide derived from the Internal region of human POLR3G.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

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PA551121

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Antigen:
GMFB

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Gmfb

Gene Alias:
3110001H22Rik; 3110001O16Rik; AI851627; C79176; D14Ertd630e; DNA for thyroid hormone receptor binding site (276bp); glia maturation factor beta; glia maturation factor beta-like protein; glia maturation factor, beta; GMF; Gmfb; GMF-beta

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
2764, 63985, 81661

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
ELISA, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P60983, Q63228, Q9CQI3

Gene Symbols:
Gmfb

Immunogen:
Synthesized peptide derived from the Internal region of human GMF-B.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

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PA551123

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Antigen:
NTS

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
NTS

Gene Alias:
5033428E16Rik; Large neuromedin N; Neuromedin N; neurotensin; Neurotensin/neuromedin N; NmN; NMN-125; NN; NT; NT/N; NTS; NTS1; pro-neurotensin/neuromedin; Tail peptide

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
299757, 4922, 67405

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
ELISA, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P20068, P30990, Q9D3P9

Gene Symbols:
NTS

Immunogen:
Synthesized peptide derived from the C-terminal region of human Neurotensin.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG