STAT5 beta Recombinant Polyclonal Antibody (13HCLC), Invitrogen™

Description

• Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
• They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
• While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
• The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
• The protein encoded by this gene is a member of the STAT family of transcription factors
• In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators
• This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones
• It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression
• This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL)
• The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.