TPL2 Recombinant Polyclonal Antibody (3HCLC), Invitrogen™

Description

• This antibody is predicted to react with bovine, canine, equine, mouse, rabbit and rat based on sequence homology
• Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
• They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
• While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
• The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
• MAP3K8 (COT) is a serine/threonine kinase which can activate both the MAP and JNK kinase pathways and plays a role in the cell cycle
• Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase (MAPKKK or MEKK)
• MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK
• The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells
• MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105
• This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines
• The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle
• The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.