PIMA1115
Huntingtin Monoclonal Antibody (3-19), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA1115-Each-of-1 | In Stock | ₹ 42,822.78 |
PIMA1115 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,822.78
GST (18%): ₹ 7,708.10
Total Price: ₹ 50,530.88
Antigen
Huntingtin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P42858, P42859
Gene Symbols
Htt
Immunogen
Synthetic peptide conjugated to KLH via cysteine corresponding to residues C-HTLQADSVD (505-513) of Human HTT.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
3-19
Conjugate
Unconjugated
Gene
Htt
Gene Alias
AI256365; C430023I11Rik; Hd; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; IT15; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
15194, 3064
Content And Storage
-20°C
Form
Liquid
Description
- MA1-115 has been successfully used in immunofluorescence, immunohistochemistry, Western Blot, and ELISA applications with human and mouse samples
- Neoepitope antibodies distinguish smaller cleaved fragments or processed forms of proteins versus the intact full-length or precursor by using a designed peptide purification process to maximize immunoreactivity to a specific cleavage site
- Human HTT caspase cleavage sites generate fragment-specific forms of the protein
- Caspase-3/7 has been shown to generate cleavage sites at animo acids 513 and 552
- Caspase-2 cleaves at amino acid 552 and caspase-6 at amino acid 586
- Neo-specific antibody MA1-057 recognizes the 513 cleaved fragment without detecting the full-length form
- Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons
- This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product
- HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons
- The huntingtin gene is widely expressed and is required for normal development
- It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues
- The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed
- The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.
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Antigen: Huntingtin
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.: P42858, P42859
Gene Symbols: Htt
Immunogen: Synthetic peptide conjugated to KLH via cysteine corresponding to residues C-HTLQADSVD (505-513) of Human HTT.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: 3-19
Conjugate: Unconjugated
Gene: Htt
Gene Alias: AI256365; C430023I11Rik; Hd; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; IT15; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 15194, 3064
Content And Storage: -20°C
Form: Liquid
Antigen:
Huntingtin
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.:
P42858, P42859
Gene Symbols:
Htt
Immunogen:
Synthetic peptide conjugated to KLH via cysteine corresponding to residues C-HTLQADSVD (505-513) of Human HTT.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
3-19
Conjugate:
Unconjugated
Gene:
Htt
Gene Alias:
AI256365; C430023I11Rik; Hd; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; IT15; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
15194, 3064
Content And Storage:
-20°C
Form:
Liquid
Antigen: TGF beta-1
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P01137
Gene Symbols: Tgfb1
Immunogen: Full length of human TGF beta-1 (Met1-Ser390) was fused with c-terminal polyhistidine tag
Quantity: 200 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: ELISA, Western Blot
Clone: E8-4D12
Conjugate: Unconjugated
Gene: Tgfb1
Gene Alias: CED; cytokine; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; tgf beta1; TGF beta-1; TGF beta-1 protein; TGF β; TGF β 1; TGF β1; Tgfb; TGFB1; TGF-B1; Tgfb-1; TGFbeta; TGF-beta 1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-1; TGFβ1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor β1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta I; transforming growth factor-beta-1; transforming growth factor-beta-1 precursor; unnamed protein product
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 7040
Content And Storage: -20°C
Form: Liquid
Antigen:
TGF beta-1
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P01137
Gene Symbols:
Tgfb1
Immunogen:
Full length of human TGF beta-1 (Met1-Ser390) was fused with c-terminal polyhistidine tag
Quantity:
200 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA, Western Blot
Clone:
E8-4D12
Conjugate:
Unconjugated
Gene:
Tgfb1
Gene Alias:
CED; cytokine; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; tgf beta1; TGF beta-1; TGF beta-1 protein; TGF β; TGF β 1; TGF β1; Tgfb; TGFB1; TGF-B1; Tgfb-1; TGFbeta; TGF-beta 1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-1; TGFβ1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor β1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta I; transforming growth factor-beta-1; transforming growth factor-beta-1 precursor; unnamed protein product
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
7040
Content And Storage:
-20°C
Form:
Liquid
Antigen: beta-3 Tubulin
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide
Gene Accession No.: Q13509, Q2T9S0, Q4QRB4, Q9ERD7
Gene Symbols: LOC100341581, TUBB3
Immunogen: A synthetic peptide corresponding to amino acids 436-450 from rat neuronal specific beta-3 tubulin.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Bovine, Guinea Pig, Hamster, Human, Mouse, Porcine, Rabbit, Rat
Product Type: Antibody
Isotype: IgG2a
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 2G10
Conjugate: Unconjugated
Gene: TUBB3
Gene Alias: 3200002H15Rik; beta 3 tubulin; beta tubulin 3; beta-4; betaIII-tubulin; CDCBM; CDCBM1; CFEOM3; CFEOM3A; class III beta-tubulin; FEOM3; I79_000194; LOC100341581; M(beta)3; M(beta)6; mc1R; melanocortin receptor 1; Neuron specific beta III Tubulin; neuron-specific class III beta-tubulin; TUBB; Tubb3; TUBB4; tubulin beta; tubulin beta 3 class III; Tubulin beta-3; tubulin beta-3 chain; Tubulin beta-4; Tubulin beta-4 chain; tubulin beta-III; tubulin, beta 3 class III; tubulin, beta, 3; tubulin, beta, 4; Unknown (protein for MGC:134115)
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 100341581, 100732882, 100760055, 10381, 106509340, 22152, 246118, 768070
Content And Storage: -20°C
Form: Liquid
Antigen:
beta-3 Tubulin
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide
Gene Accession No.:
Q13509, Q2T9S0, Q4QRB4, Q9ERD7
Gene Symbols:
LOC100341581, TUBB3
Immunogen:
A synthetic peptide corresponding to amino acids 436-450 from rat neuronal specific beta-3 tubulin.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Bovine, Guinea Pig, Hamster, Human, Mouse, Porcine, Rabbit, Rat
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
2G10
Conjugate:
Unconjugated
Gene:
TUBB3
Gene Alias:
3200002H15Rik; beta 3 tubulin; beta tubulin 3; beta-4; betaIII-tubulin; CDCBM; CDCBM1; CFEOM3; CFEOM3A; class III beta-tubulin; FEOM3; I79_000194; LOC100341581; M(beta)3; M(beta)6; mc1R; melanocortin receptor 1; Neuron specific beta III Tubulin; neuron-specific class III beta-tubulin; TUBB; Tubb3; TUBB4; tubulin beta; tubulin beta 3 class III; Tubulin beta-3; tubulin beta-3 chain; Tubulin beta-4; Tubulin beta-4 chain; tubulin beta-III; tubulin, beta 3 class III; tubulin, beta, 3; tubulin, beta, 4; Unknown (protein for MGC:134115)
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
100341581, 100732882, 100760055, 10381, 106509340, 22152, 246118, 768070
Content And Storage:
-20°C
Form:
Liquid
Antigen: RhoA/RhoC
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide
Gene Accession No.: P08134, P61586, P61589, Q62159, Q9QUI0
Gene Symbols: RHOA, RHOC
Immunogen: Full-length human recombinant RhoA protein.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 1B3-4A10
Conjugate: Unconjugated
Gene: RHOC
Gene Alias: AI324259; Aplysia ras-related homolog 12; aplysia ras-related homolog 9 (RhoC); aplysia ras-related homolog A; aplysia ras-related homolog A1; aplysia ras-related homolog A2; ARH12; ARH9; ARHA; Arha1; Arha2; Arhc; h12; H9; oncogene RHO H12; oncogene RHO H9; plysia ras-related homolog A2; Ras family member A; ras homolog 9 (RhoC); ras homolog A1; ras homolog A2; ras homolog family member A; ras homolog family member C; ras homolog gene family, member A; ras homolog gene family, member A1; ras homolog gene family, member A2; ras homolog gene family, member C; RAS-related homolog 9; Rho; Rho cDNA clone 12; Rho cDNA clone 9; Rho family GTPase; RHO12; Rhoa; Rhoc; rhoC GTPase; RHOH12; RHOH9; rho-related GTP-binding protein RhoC; SIG-61; silica-induced gene 61 protein; small GTP binding protein RhoA; small GTP binding protein RhoC; transforming protein RhoA
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 117273, 11848, 11853, 295342, 387, 389
Content And Storage: -20°C
Form: Liquid
Antigen:
RhoA/RhoC
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide
Gene Accession No.:
P08134, P61586, P61589, Q62159, Q9QUI0
Gene Symbols:
RHOA, RHOC
Immunogen:
Full-length human recombinant RhoA protein.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
1B3-4A10
Conjugate:
Unconjugated
Gene:
RHOC
Gene Alias:
AI324259; Aplysia ras-related homolog 12; aplysia ras-related homolog 9 (RhoC); aplysia ras-related homolog A; aplysia ras-related homolog A1; aplysia ras-related homolog A2; ARH12; ARH9; ARHA; Arha1; Arha2; Arhc; h12; H9; oncogene RHO H12; oncogene RHO H9; plysia ras-related homolog A2; Ras family member A; ras homolog 9 (RhoC); ras homolog A1; ras homolog A2; ras homolog family member A; ras homolog family member C; ras homolog gene family, member A; ras homolog gene family, member A1; ras homolog gene family, member A2; ras homolog gene family, member C; RAS-related homolog 9; Rho; Rho cDNA clone 12; Rho cDNA clone 9; Rho family GTPase; RHO12; Rhoa; Rhoc; rhoC GTPase; RHOH12; RHOH9; rho-related GTP-binding protein RhoC; SIG-61; silica-induced gene 61 protein; small GTP binding protein RhoA; small GTP binding protein RhoC; transforming protein RhoA
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
117273, 11848, 11853, 295342, 387, 389
Content And Storage:
-20°C
Form:
Liquid