CD26 Monoclonal Antibody (M-A261), Invitrogen™

Description

• The epitope recognized by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing
• For immunohistochemistry, we recommend the use of acetone fixation for frozen sections
• CD26 (dipeptidyl peptidase IV, DPP IV), adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family
• CD26 is expressed on lymphocyte cells and is upregulated during T-cell activation
• CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia
• CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection
• CD26 identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26
• Further, CD26 is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides
• Alterations in CD26 peptidase activity are characteristic of malignant transformation, and the enzymatic activity increases dramatically with tumor grade and severity
• CD26 is expressed in various blood cell types, but also in cells that are histogenetically related to activated fibroblasts
• Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.