PIMA134820

Cyclin D1 Monoclonal Antibody (CD1.1), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIMA134820-Each-of-1 In Stock ₹ 39,785.40

PIMA134820 - Each of 1

₹ 39,785.40

In Stock

Quantity

1

Base Price: ₹ 39,785.40

GST (18%): ₹ 7,161.372

Total Price: ₹ 46,946.772

Antigen

Cyclin D1

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with 0.09% sodium azide

Gene Accession No.

P24385, P39948

Gene Symbols

CCND1

Immunogen

Human Cyclin D1

Quantity

20 μg

Primary or Secondary

Primary

Target Species

Human, Rat

Product Type

Antibody

Isotype

IgG1

Applications

Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone

CD1.1

Conjugate

Unconjugated

Gene

CCND1

Gene Alias

AI327039; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1; BCL-1 oncogene; CCND1; CCND1 protein; cD1; cDNA; CycD1; cyclin D1; Cyl-1; D11S287E; FLJ93625; G1/S-specific cyclin-D1; mRNA; PRAD1; PRAD-1; PRAD1 oncogene; U21B31

Host Species

Mouse

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

58919, 595

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

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Description

  • MA1-34820 detects Cyclin D1 from human samples
  • Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein
  • Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL)
  • In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation
  • In humans, the CCND1 gene encoding cyclin D1 is present on chromosome 11
  • Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation
  • D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1
  • Without growth factor-mediated stimulation, Cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation
  • Cyclin D1 destabilization participates in G1/S phase arrest
  • The Cyclin D1 protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle
  • Cyclins function as regulators of CDK kinases
  • Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event
  • Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition
  • The Cyclin D1 protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb
  • Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis
  • Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.

Compare Similar Items

Show Difference

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Thermo Scientific

PIMA134820

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Antigen:
Cyclin D1

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
P24385, P39948

Gene Symbols:
CCND1

Immunogen:
Human Cyclin D1

Quantity:
20 μg

Primary or Secondary:
Primary

Target Species:
Human, Rat

Product Type:
Antibody

Isotype:
IgG1

Applications:
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone:
CD1.1

Conjugate:
Unconjugated

Gene:
CCND1

Gene Alias:
AI327039; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1; BCL-1 oncogene; CCND1; CCND1 protein; cD1; cDNA; CycD1; cyclin D1; Cyl-1; D11S287E; FLJ93625; G1/S-specific cyclin-D1; mRNA; PRAD1; PRAD-1; PRAD1 oncogene; U21B31

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
58919, 595

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Img

Thermo Scientific

PIMA134918

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Antigen:
Pancreatic Amylase

Classification:
Monoclonal

Concentration:
0.6 mg/mL

Formulation:
PBS with no preservative; pH 7.4

Gene Accession No.:
P04746, P19961

Gene Symbols:
AMY2A, AMY2B

Immunogen:
Full length protein. Human Pancreatic Amylase.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgM

Applications:
ELISA

Clone:
501

Conjugate:
Unconjugated

Gene:
AMY2B

Gene Alias:
1,4-alpha-D-glucan glucanohydrolase; 1,4-alpha-D-glucan glucanohydrolase 2B; alpha-amylase; Alpha-amylase 2B; Amy2; Amy2-1; Amy2-2; Amy2a; Amy2a1; Amy2a4; AMY2B; AMY3; amylase; amylase 2-2, pancreatic; amylase 2a1; amylase 2a4; amylase 2a4, pancreatic; amylase 2b; amylase 2b, pancreatic; amylase, alpha 2A (pancreatic); amylase, alpha 2B (pancreatic); Amy-X; carcinoid alpha-amylase; ENSMUSG00000074267; glycogenase; HXA; mAmy2-1; mAmy2-3; mAmy2-6; OTTMUSG00000022432; OTTMUSG00000022433; OTTMUSG00000022462; PA; Pancreatic alpha-amylase; pancreatic amylase alpha 2A

Host Species:
Mouse

Purification Method:
PEG precipitation

Regulatory Status:
RUO

Gene ID (Entrez):
279, 280

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Img

Thermo Scientific

PIMA134966

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Antigen:
Calpain S1/S2

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 3mM sodium azide; pH 7.5

Gene Accession No.:
P04632, P13135, Q96L46

Gene Symbols:
CAPNS1, CAPNS2

Immunogen:
Full length protein (Human). Antibody specifically recognizes small subunit.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Bovine, Human

Product Type:
Antibody

Isotype:
IgG1

Applications:
ELISA, Immunoprecipitation, Western Blot

Clone:
28F3

Conjugate:
Unconjugated

Gene:
CAPNS1

Gene Alias:
2310005G05Rik; 30K-2; calcium-activated neutral proteinase 2; Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit; Calcium-dependent protease small subunit 1; calcium-dependent protease small subunit 2; calcium-dependent protease, small subunit; calpain 2; calpain 2, (m/II) large subunit; calpain 2, large [catalytic] subunit; calpain 2, large subunit; calpain 4; calpain 4, small subunit (30K); calpain II regulatory subunit; calpain II regulatory subunit (EC 3.4.22.17); calpain large polypeptide L2; Calpain M-type; calpain regulatory subunit; Calpain small subunit 1; calpain small subunit 2; calpain, large polypeptide L2; calpain, small polypeptide; calpain, small subunit 1; calpain, small subunit 2; calpain-2 catalytic subunit; Calpain-2 large subunit; CALPAIN4; CANP; CANP 2; CANP small subunit; CANP2; CANPL2; CANPml; CANPS; Capa4; Capa-4; CAPN2; Capn4; CAPNS; CAPNS1; Capns2; CDPS; CSS1; CSS2; D7Ertd146e; M-calpain; mCANP; Millimolar-calpain

Host Species:
Mouse

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
100300424, 281664, 826, 84290

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Img

Thermo Scientific

PIMA135368

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Antigen:
Cytokeratin Pan Type II

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
antibody with 0.1% sodium azide

Gene Accession No.:
O93532, P02538, P04104, P04264, P05786, P05787, P07744, P08729, P11679, P12035, P13647, P19013, P35908, P50446, Q01546, Q10758, Q148H8, Q14CN4, Q29426, Q29S21, Q3TTY5, Q3UV17, Q4FZU2, Q5XQN5, Q6IG00, Q6IG02, Q6IG04, Q6IG12, Q6IME9, Q6IMF3, Q6P6Q2, Q922U2, Q9DCV7

Gene Symbols:
KRT1, KRT2, KRT3, KRT4, KRT5, Krt6a, KRT7, KRT72, KRT76, KRT8

Immunogen:
Human epidermal keratin.

Quantity:
250 μg

Primary or Secondary:
Primary

Target Species:
Bovine, Chicken, Human, Mouse, Rabbit, Rat

Product Type:
Antibody

Isotype:
IgG1

Applications:
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot

Clone:
AE3

Conjugate:
Unconjugated

Gene:
KRT7

Gene Alias:
2310016L08Rik; 3300001P10Rik; 57kd keratin; 57kDa keratin; 58 kda cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; AA960620; AI507495; AL022697; alpha keratin; AU019895; AW108092; AW146334; BB005427; Card2; CK 2e; CK1; CK-1; CK-2e; CK3; CK-3; CK4; CK-4; CK5; CK-5; CK6A; CK-6A; CK6C; CK-6C; CK6D; CK-6D; CK-6E; CK7; CK-7; CK-72; CK8; CK-8; CYK4; CYK8; CYKER; cytokeratin 1; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; cytokeratin 7; cytokeratin 8; cytokeratin 8 (370 AA); cytokeratin endo A; Cytokeratin otokeratin; cytokeratin type II, component Ib/c; cytokeratin type II, component III; Cytokeratin-1; Cytokeratin-2e; cytokeratin-3; Cytokeratin-4; cytokeratin-5; Cytokeratin-6A; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; cytokeratin-7; Cytokeratin-72; cytokeratin-8; Cytokeratin-A; cytoskeletal 57 kDa keratin; D15Wsu77e; DDD; DDD1; ear specific cytokeratin; EBS2; EGK_03684; EGK_03685; EHK; EHK1; EndoA; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; epithelial keratin 1; epithelial keratin 2e; Epithelial keratin-1; Epithelial keratin-2e; EPPK; Hair alpha protein; Hom s 5; K1; K2C7; K2C8; K2E; K3; K3 keratin; K4; K5; K6A; K6a keratin; K6C; K6D; K6irs; K6IRS2; K7; K72; K8; kamp-keratin derived antimicrobial peptide; Kb1; Kb2; Kb35; Kb4; Kb7; KDAMP; KER1; Ker2; KERA; keratin; keratin 1; keratin 1 (epidermolytic hyperkeratosis); keratin 1, type II; keratin 2; keratin 2 (epidermal ichthyosis bullosa of Siemens); keratin 2 epidermis; keratin 2, type II; keratin 2A; keratin 2A (epidermal ichthyosis bullosa of Siemens); keratin 3; keratin 3, type II; keratin 4; keratin 4, type II; keratin 5; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6 alpha; keratin 6, inner root sheath, 2; keratin 6A; keratin 6A, , type II; keratin 6A, type II; keratin 7; keratin 7, type II; keratin 72; keratin 72, pseudogene; keratin 72, type II; keratin 8; keratin 8, type II; keratin 86; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 35; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; keratin IV; keratin K3; keratin K6; keratin K6h; keratin protein K6irs; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 2 epidermal; keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 59 kDa, component IV; keratin, type II cytoskeletal 60 kDa, component III; keratin, type II cytoskeletal 6A; keratin, type II cytoskeletal 6C; keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 72; keratin, type II cytoskeletal 8; Keratin, type II cytoskeletal cochleal; keratin-1; Keratin-2 epidermis; keratin-2e; Keratin-3; Keratin-4; keratin-5; keratin-6A; Keratin-6-alpha; keratin-6C; keratin-7; Keratin-72; keratin-8; KERIB; KO; Krt1; krt1 {ECO:0000250; KRT1A; Krt2; krt2 {ECO:0000250; Krt-2.1; Krt-2.4; Krt-2.8; Krt2-1; Krt2-17; Krt2-2; Krt2-35; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; KRT2-8; KRT2A; KRT2E; KRT3; KRT4; krt4 {ECO:0000250; Krt5; KRT5A; KRT6; Krt6a; KRT6C; KRT6D; KRT6IRS2; Krt7; krt7 {ECO:0000250; Krt72; Krt72-ps; Krt8; Krt86; KRTA; KRTE; LOC683313; LOW QUALITY PROTEIN: keratin, type II cytoskeletal 7; MGC116967; MGC116968; mK6[a]; MK6a; mK6-alpha; NEPPK; otokeratin; pan keratin; PC3; Sak57; sarcolectin; SCL; similar to keratin 7; similar to keratin complex 2, basic, gene 6a; Tfip8; tuftelin interacting protein 8

Host Species:
Mouse

Purification Method:
purified

Regulatory Status:
RUO

Gene ID (Entrez):
100301161, 100345579, 100348388, 100348891, 100352658, 100353162, 100353415, 100353668, 105866, 110308, 110310, 120093743, 140807, 16678, 16681, 16682, 16687, 16691, 25626, 281268, 281269, 300242, 300250, 315323, 369017, 3848, 3849, 3850, 3851, 3852, 3853, 3855, 3856, 395772, 406227, 406228, 407188, 407189, 407757, 407779, 408041, 426896, 51350, 527819, 531057, 535697, 614456, 768882, 769040, 77055, 786381

Content And Storage:
4° C

Form:
Liquid