PIMA512252

Pds1 Monoclonal Antibody (DCS-280), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIMA512252-Each-of-1 In Stock ₹ 47,956.38

PIMA512252 - Each of 1

₹ 47,956.38

In Stock

Quantity

1

Base Price: ₹ 47,956.38

GST (18%): ₹ 8,632.148

Total Price: ₹ 56,588.528

Antigen

Pds1

Classification

Monoclonal

Concentration

0.2 mg/mL

Formulation

PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4

Gene Accession No.

P01344, P09535

Gene Symbols

IGF2

Immunogen

Human recombinant full length Pds1 protein

Quantity

500 μL

Primary or Secondary

Primary

Target Species

Human, Mouse

Product Type

Antibody

Isotype

IgG2a κ

Applications

Immunohistochemistry (Paraffin), Western Blot

Clone

DCS-280

Conjugate

Unconjugated

Gene

IGF2

Gene Alias

AL033362; C11orf43; GRDF; Igf2; Igf-2; IGF-II; insulin like growth factor 2; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; insulin-like growth factor type 2; M6pr; Mpr; multiplication-stimulating polypeptide; Peg2; PP1446; PP9974; preptin; somatomedin A; Somatomedin-A; T3M-11-derived growth factor

Host Species

Mouse

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

16002, 3481

Content And Storage

4° C

Form

Liquid

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Description

  • IHC staining of formalin-fixed tissues requires boiling in 10mM citrate buffer, pH 6.0, for 10-20 minutes, followed by cooling at room temperature for 20 minutes
  • HeLa or tonsil tissues can be used as positive controls
  • Pds1 is an anaphase inhibitor and plays important role in DNA damage and spindle check point pathways
  • Pds1 inhibits sister chromatid separation by binding and inhibiting Esp1, cystein protease that causes cleavage of the cohesin Scc1 that binds the sister chromatids together
  • Pds1 is responsible for targeting of Esp1 to nucleus and its binding to the spindle
  • Degradation of Pds1 occurs shortly before anaphase, which liberates Esp1 and is a prerequisite for anaphase entry
  • Pds1 is targeted for degradation by ubiquitination mediated by cyclosome/anaphase-promoting complex (APC) functioning as a ubiquitin ligase
  • In response to DNA damage Chk1 phosphorylates Pds1 to stabilize it against the APC mediated destruction, hence preventing the entry of such a cell into anaphase.

Compare Similar Items

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Img

Thermo Scientific

PIMA512252

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Antigen:
Pds1

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4

Gene Accession No.:
P01344, P09535

Gene Symbols:
IGF2

Immunogen:
Human recombinant full length Pds1 protein

Quantity:
500 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG2a κ

Applications:
Immunohistochemistry (Paraffin), Western Blot

Clone:
DCS-280

Conjugate:
Unconjugated

Gene:
IGF2

Gene Alias:
AL033362; C11orf43; GRDF; Igf2; Igf-2; IGF-II; insulin like growth factor 2; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; insulin-like growth factor type 2; M6pr; Mpr; multiplication-stimulating polypeptide; Peg2; PP1446; PP9974; preptin; somatomedin A; Somatomedin-A; T3M-11-derived growth factor

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
16002, 3481

Content And Storage:
4° C

Form:
Liquid

Img

Thermo Scientific

PIMA512259

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Antigen:
CD4

Classification:
Monoclonal

Concentration:
Conc. Not Determined

Formulation:
tissue culture supernatant with 0.09% sodium azide

Gene Accession No.:
P01730

Gene Symbols:
CD4

Immunogen:
Stimulated human leukocytes

Quantity:
500 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1 κ

Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot

Clone:
4B12

Conjugate:
Unconjugated

Gene:
CD4

Gene Alias:
Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen

Host Species:
Mouse

Purification Method:
__

Regulatory Status:
RUO

Gene ID (Entrez):
920

Content And Storage:
4° C

Form:
Liquid

Img

Thermo Scientific

PIMA512272

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Antigen:
alpha Synuclein

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4

Gene Accession No.:
P37377, P37840

Gene Symbols:
SNCA

Immunogen:
Human recombinant alpha-synuclein

Quantity:
500 μL

Primary or Secondary:
Primary

Target Species:
Human, Rat

Product Type:
Antibody

Isotype:
IgG1

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone:
Syn 211

Conjugate:
Unconjugated

Gene:
SNCA

Gene Alias:
Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)

Host Species:
Mouse

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
29219, 6622

Content And Storage:
4° C

Form:
Liquid

Img

Thermo Scientific

PIMA512287

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Antigen:
CD99

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4

Gene Accession No.:
P14209

Gene Symbols:
CD99

Immunogen:
MeWo human melanoma cells

Quantity:
500 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Clone:
O13

Conjugate:
Unconjugated

Gene:
CD99

Gene Alias:
1110061M03Rik; 12E7; 2410026K10Rik; antigen identified by monoclonal 12E7, Y homolog; antigen identified by monoclonal antibodies 12E7, F21 and O13; Cd99; CD99 antigen; CD99 molecule; cell surface antigen 12E7; cell surface antigen HBA-71; cell surface antigen O13; D4; E2 antigen; HBA71; MIC2; MIC2 (monoclonal antibody 12E7); MIC2X; MIC2Y; MSK5X; paired immunoglobin-like type 2 receptor-ligand; pilr-1; Pilrl; PILR-L; Protein MIC2; surface antigen MIC2; T-cell surface glycoprotein E2

Host Species:
Mouse

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
4267

Content And Storage:
4° C

Form:
Liquid