BMPR2 Monoclonal Antibody (1F12), Invitrogen™

Description

• MA5-15826 targets BMPR2 in indirect ELISA, IHC and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples
• The MA5-15826 immunogen is purified recombinant fragment of human BMPR2 expressed in E
• Coli
• MA5-15826 detects BMPR2 which has a predicted molecular weight of approximately 115kDa
• BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases
• The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis
• The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation
• BMPs are involved in endochondral bone formation and embryogenesis
• These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa
• Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding
• Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.