PIMA516012
HIF-1 beta Monoclonal Antibody (H1beta234), DyLight™ 650, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516012-Each-of-1 | In Stock | ₹ 47,956.38 |
PIMA516012 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,956.38
GST (18%): ₹ 8,632.148
Total Price: ₹ 56,588.528
Antigen
HIF-1 beta
Classification
Monoclonal
Concentration
1.4 mg/mL
Formulation
50mM sodium borate with no preservative
Gene Accession No.
P27540, P41739, P53762, Q9BE97
Gene Symbols
ARNT
Immunogen
Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
H1beta234
Conjugate
DyLight 650
Gene
ARNT
Gene Alias
AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
11863, 25242, 281010, 405, 443285
Content And Storage
4° C, store in dark
Form
Liquid
Related Products
Description
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
- This occurs as a posttranslational modification by prolyl hydroxylation
- HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
- Both subunits are constantly translated
- However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
- Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
- Therefore, the concentration of HIF-1 alpha increases in the cell
- In contrast, HIF-1 beta remains stable under either condition
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
- This occurs as a posttranslational modification by prolyl hydroxylation
- HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
- Both subunits are constantly translated
- However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
- Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
- Therefore, the concentration of HIF-1 alpha increases in the cell
- In contrast, HIF-1 beta remains stable under either condition
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.
Compare Similar Items
Show Difference
Antigen: HIF-1 beta
Classification: Monoclonal
Concentration: 1.4 mg/mL
Formulation: 50mM sodium borate with no preservative
Gene Accession No.: P27540, P41739, P53762, Q9BE97
Gene Symbols: ARNT
Immunogen: Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type: Antibody
Isotype: IgG1 κ
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: H1beta234
Conjugate: DyLight 650
Gene: ARNT
Gene Alias: AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 11863, 25242, 281010, 405, 443285
Content And Storage: 4° C, store in dark
Form: Liquid
Antigen:
HIF-1 beta
Classification:
Monoclonal
Concentration:
1.4 mg/mL
Formulation:
50mM sodium borate with no preservative
Gene Accession No.:
P27540, P41739, P53762, Q9BE97
Gene Symbols:
ARNT
Immunogen:
Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
H1beta234
Conjugate:
DyLight 650
Gene:
ARNT
Gene Alias:
AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
11863, 25242, 281010, 405, 443285
Content And Storage:
4° C, store in dark
Form:
Liquid
Antigen: HIF-1 beta
Classification: Monoclonal
Concentration: 0.72 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P27540, P41739, P53762, Q9BE97
Gene Symbols: ARNT
Immunogen: Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type: Antibody
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: H1beta234
Conjugate: HRP
Gene: ARNT
Gene Alias: AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 11863, 25242, 281010, 405, 443285
Content And Storage: 4° C, store in dark
Form: Liquid
Antigen:
HIF-1 beta
Classification:
Monoclonal
Concentration:
0.72 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P27540, P41739, P53762, Q9BE97
Gene Symbols:
ARNT
Immunogen:
Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
H1beta234
Conjugate:
HRP
Gene:
ARNT
Gene Alias:
AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
11863, 25242, 281010, 405, 443285
Content And Storage:
4° C, store in dark
Form:
Liquid
Antigen: HIF-1 beta
Classification: Monoclonal
Concentration: 1.03 mg/mL
Formulation: 50mM sodium borate with 0.05% sodium azide
Gene Accession No.: P27540, P41739, P53762, Q9BE97
Gene Symbols: ARNT
Immunogen: Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type: Antibody
Isotype: IgG1 κ
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: H1beta234
Conjugate: DyLight 550
Gene: ARNT
Gene Alias: AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 11863, 25242, 281010, 405, 443285
Content And Storage: 4° C, store in dark
Form: Liquid
Antigen:
HIF-1 beta
Classification:
Monoclonal
Concentration:
1.03 mg/mL
Formulation:
50mM sodium borate with 0.05% sodium azide
Gene Accession No.:
P27540, P41739, P53762, Q9BE97
Gene Symbols:
ARNT
Immunogen:
Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
H1beta234
Conjugate:
DyLight 550
Gene:
ARNT
Gene Alias:
AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
11863, 25242, 281010, 405, 443285
Content And Storage:
4° C, store in dark
Form:
Liquid
Antigen: HIF1A
Classification: Monoclonal
Concentration: 0.65 mg/mL
Formulation: PBS with 0.05% sodium azide
Gene Accession No.: O35800, Q16665, Q61221, Q9XTA5
Gene Symbols: HIF1A
Immunogen: Human HIF-1 alpha amino acids 329-530.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Canine, Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone: ESEE122
Conjugate: Biotin
Gene: HIF1A
Gene Alias: AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; bHLHe78; Class E basic helix-loop-helix protein 78; HIF; hif 1; hif 1a; HIF1; HIF1 alpha; HIF-1 alpha; HIF1a; hif-1a; hif1a.L; HIF1alpha; HIF-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor-1 alpha; hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1 alpha subunit; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; hypoxia-inducible factor 1-alpha; hypoxia-inducible factor-1 alpha; hypoxia-inducible factor1alpha; member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8; XELAEV_18039792mg; XELAEV_18041137mg; xhif1a
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 15251, 281814, 29560, 3091, 480348
Content And Storage: 4° C, store in dark
Form: Liquid
Antigen:
HIF1A
Classification:
Monoclonal
Concentration:
0.65 mg/mL
Formulation:
PBS with 0.05% sodium azide
Gene Accession No.:
O35800, Q16665, Q61221, Q9XTA5
Gene Symbols:
HIF1A
Immunogen:
Human HIF-1 alpha amino acids 329-530.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Canine, Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone:
ESEE122
Conjugate:
Biotin
Gene:
HIF1A
Gene Alias:
AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; bHLHe78; Class E basic helix-loop-helix protein 78; HIF; hif 1; hif 1a; HIF1; HIF1 alpha; HIF-1 alpha; HIF1a; hif-1a; hif1a.L; HIF1alpha; HIF-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor-1 alpha; hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1 alpha subunit; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; hypoxia-inducible factor 1-alpha; hypoxia-inducible factor-1 alpha; hypoxia-inducible factor1alpha; member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8; XELAEV_18039792mg; XELAEV_18041137mg; xhif1a
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
15251, 281814, 29560, 3091, 480348
Content And Storage:
4° C, store in dark
Form:
Liquid